We report a case of measles inclusion-body encephalitis (MIBE) occurring in an apparently healthy 21-month-old boy 8.5 months after measles-mumps-rubella vaccination. He had no prior evidence of immune deficiency and no history of measles exposure or clinical disease. During hospitalization, a primary immunodeficiency characterized by a profoundly depressed CD8 cell count and dysgammaglobulinemia was demonstrated.

A brain biopsy revealed histopathologic features consistent with MIBE, and measles antigens were detected by immunohistochemical staining. Electron microscopy revealed inclusions characteristic of paramyxovirus nucleocapsids within neurons, oligodendroglia, and astrocytes. The presence of measles virus in the brain tissue was confirmed by reverse transcription polymerase chain reaction. The nucleotide sequence in the nucleoprotein and fusion gene regions was identical to that of the Moraten and Schwarz vaccine strains; the fusion gene differed from known genotype A wild-type viruses.

Vaccines - Hepatitis Vaccine

The neurologic injury that causes ADD is undoubtedly aggravated by allergy and low blood sugar and these should rightfully be treated. But they are not likely the cause of the disorder. Nevertheless, treating allergy and balancing the diet can make a huge difference. Just ask the mothers and fathers of the Feingold Association how they feel about food additives, salicylates, and allergy.

The same goes for parents who find that sugar is a trigger for hyperactivity: would you have them believe an egghead statistic over their own first-hand, day-to-day experience?

The New England Journal apparently would. Their recent study on the effects of sugar was thumbs down: no significant effect of sugar on child behavior! This study, by Dr. Wolraich et al, was designed so that the average dose of sugar was about 2/3 pound (300 grams) a day. There was no comparison group at a truly low sugar intake, under 100 mg per day. I wrote to them about this but my rebuttal was rejected. I called the editor; he assured me that the other critics also felt that the study should be repeated— but with a higher dose of sugar!

Jim and Star Chavez didn't think twice when their doctor prescribed Advair for their son Ethan. 

Inhaled daily, Advair was supposed to prevent his occasional mild asthma attacks. Instead, as CBS News Correspondent Sharyl Attkisson reports, shortly after he started using Advair, Ethan collapsed.

"He was totally lifeless," says Jim Chavez. "His eyes were rolled back in his head, and it was really terrifying."

"I shook him, and I kept on shaking him and kept on yelling his name, 'Ethan, Ethan, wake up, wake up,' and he wouldn't respond at all," says Star Chavez.

They didn't know it then, but asthma patients taking the same medicine in a study were dying in unexpected numbers. 

Drugmaker GlaxoSmithKline led a study of Salmeterol, the medicine in Advair and another Glaxo asthma product, Serevent. Designed to relieve asthma, it seemed to trigger fatal attacks in some. Three times more patients taking the medicine died of asthma than those not taking it. 

A safety monitoring board took one look at the deaths and shut down Glaxo's study. The FDA recently forced Glaxo to disclose the small but significant risk of death in a black box warning on its medicine and in ads: "Rare but serious asthma episodes and asthma related fatalities occurred."

In the study, Glaxo found deaths among blacks were the highest, though white deaths were also elevated. Glaxo then sent out a carefully worded message that led some to believe white patients need not worry: "These risks may be greater in African-Americans."

Yet CBS News has learned a study ten years ago of only white patients also found an increase in asthma deaths. Glaxo dismissed the deaths back then as "probably due to the disease rather than the treatment."

Most people who use Advair have no serious problems, and the FDA says benefits outweigh risks. And despite the new warnings, sales have increased, approaching $2 billion a year. 

And that black box warning ordered for Advair four months ago still isn't on the product. The FDA says Glaxo negotiated when it will be but won't tell CBS News the date.

Ethan has fully recovered from his trauma, and the whole family is breathing easier without the asthma remedy that may have been worse than the disease.

However, no properly confirmed tumor regression was reported so far in all probability because of neither theoretical nor experimental grounds for this proposal. The presence of cesium in the cell does not guarantee high pH of its content, and there is no clinical evidence to support the claims that cancer cells are vulnerable to cesium. Cesium is relatively safe; signs of its mild toxicity are gastrointestinal distress, hypotension, syncope, numbness, or tingling of the lips.

Nevertheless, total cesium intakes of 6 g/day have been found to produce severe hypokalemia, hypomagnesemia, prolonged QTc interval, episodes of polymorphic ventricular tachycardia, with or without torsade de pointes, and even acute heart arrest. However, full information on its acute and chronic toxicity is not sufficiently known. Health care providers should be aware of the cardiac complications, as a result of careless cesium usage as alternative medicine.

Currently we have been brainwashed by a 50 year propaganda campaign to blame our major health problems on fat and cholesterol.  At the same time, it was, illegal to make claims that health problems could be caused by mineral-depleted soils or that health benefits were obtainable by means of vitamin and mineral supplements. 

The American people were kept in the dark.  Physicians who spoke out were ridiculed, censured, and occasionally lost their license! 

That is why there are so few nutrition-physicians in America today.  There are lots of nutritionists with other degrees or no professional degree at all, but there are almost no qualified and experienced physician nutrition specialists.  Most doctors have been misled by their training in a way that denies the importance of nutrition. The de facto situation in American Medicine remains: “put nutrition last.”  

Please note that due to FDA regulations, testimonials involving overcoming disease conditions have been removed.

Formaldehyde - Methylene Glycol - Methandiol

Selenite can reduce the nephro-toxicity of cisplatin without reducing the antitumor activity of the drug.

Available information suggests that maté drinking is a risk factor for upper aerodigestive tract cancer.

THEME - METABOLISM & CANCER

Researchers working with Nahum Sonenberg and Russell Jones have discovered that the effect of certain cancer treatments can be dramatically improved when combined with specific treatments for metabolic disease. They have developed a drug – Metformin – that significantly enhances cancer treatment outcomes. Ongoing research is targeting other genes that affect the interaction between cancer cells and their energy sources. Metabolic diseases, such as obesity, are the second highest risk factor for cancer after tobacco.

GCRC scientists have discovered that certain genes that appear to contribute to carcinogenic phenotypes, are also implicated in metabolic control among patients with diabetes and obesity. This has prompted a major research initiative aimed at establishing a metabolic profile that will offer new clues about key factors involved in cancer development.

Cancer occurs when cells divide uncontrollably. It is not surprising that cancer cells display metabolic changes to meet their high energy demands. One key metabolic property of certain cancer cells is their glucose addiction, which is used in clinics to detect tumours by visualization of the glucose analog fluorodeoxyglucose (FDG) using position emission tomography (PET).

Importantly, there is a positive correlation between tumors reliance on glucose metabolism, their aggressiveness and poor clinical outcome. Additionally, genes which appear to contribute to carcinogenic phenotypes have also been implicated in the metabolic control of individuals with diabetes, obesity and other metabolic pathologies.  Given that the metabolic status of tumors and surrounding cells contributes to the aggressiveness and “dynamic nature” of cancer cells, the Centre’s team aims to elucidate the molecular pathways controlling cancer cell metabolism and learn more about key metabolite changes, as well as the molecules orchestrating them, during cancer development. 

The research program will lead to the establishment of an advanced metabolomic platform for the profiling of different metabolites from blood and tissue extracts, coming from animal models of cancer as well as from cancer patients. This will allow physicians and scientists to follow the disease progression of patients and correlate it with specific metabolite changes, leading to the identification of unique biomarkers and potential targets for treatments. 

As the group already has access to an extensive sample collection from mouse and human studies, its goal is to bring together scientists specializing in the field of genetics, molecular biology and biochemistry of cancer, and metabolism.

http://cancercentre.mcgill.ca/research/index.php?searchword=oxygen&ordering=&searchphrase=all&option=com_search&lang=en

THEME - EMBRYONIC DEVELOPMENT & CANCER

An outstanding group of embryologists and gene expression researchers examine the early mechanisms of cell movement, proliferation, organ formation, gene regulation and initial tumor formation in mammalian embryos. 

Normal embryonic development requires a fine regulation of cell proliferation, differentiation, migration and apoptosis. During embryo development, cellular interactions trigger specific events to occur. These cell behaviors are also the ones that are deregulated during tumor formation and metastasis. Key regulators are also known to act as tumor suppressors or tumor-promoting factors. 

By understanding more about the mechanisms occurring during embryonic and postnatal development, more can be understood about the molecular mechanisms underlying developmental diseases and cancer.

The research group focuses on the genetic and epigenetic determinants of embryonic and postnatal development, as well as tissue homeostasis, to better understand the molecular mechanisms underlying developmental diseases and cancer. The team has focused on the:

•    Effect of epigenetic modifications on gene regulation and embryo development
•    Role of microRNAs in mRNA polyadenylation and stability
•    Transcriptional control of cell proliferation and genomic integrity
•    Signaling and transcriptional networks driving cell lineage specification, cell polarity, organ morphogenesis and aging

Experimental approaches applied involve; biochemical methods; cell-based assays and genetic manipulations in multiple biological systems, including model organisms like the mouse and Caenorhabditis elegans; clinical samples; primary culture cells and transformed cell lines established from tumor samples.

http://cancercentre.mcgill.ca/research/index.php?searchword=oxygen&ordering=&searchphrase=all&option=com_search&lang=en

THEME - DNA REPLICATION, REPAIR & APOPTOSIS

Programmed cell death is a controlled form of cell elimination and is executed by a process termed apoptosis. Many cell-intrinsic pathways are able to activate apoptosis, commensurate with the diverse roles that programmed cell death plays in development, immunity and disease. Apoptosis occurs in response to cell stress signals, including those associated with oncogenesis and DNA damage.

One of its characteristics is the controlled disassembly of the cell into apoptotic bodies, which are eliminated. Since oncogenic stress signals are inducers of apoptosis, this cell death pathway must be suppressed in most forms of cancer. This is typically achieved by mutations that inactivate promoters of apoptosis, such as the tumor suppressor p53 and other guardians of DNA integrity. Alternatively, cell death is inhibited by dominant suppressors of apoptosis, such as the Bc1-2 family of death suppressors. Execution of the intrinsic cell apoptosis pathway involves critical transformations in the mitochondria and endoplasmic reticulum, which lead ultimately to the activation of a class of cysteine proteases, named capases, which are responsible for the demise of the cell.

The ability to re-activate the otherwise suppressed apoptosis machinery in cancer cells represents a therapeutic opportunity, and this opportunity is being examined, in order to discover ways to manipulate key regulators of the apoptotic pathways. A detailed understanding of apoptosis and uncovering its “Achilles heel” in various contexts could provide advances in the treatment of cancer. Our research programme will continue to focus on understanding the role of intracellular pathways and identify the key molecular players of apoptosis and other cell death pathways that may be of importance in cancer or virus infection.

http://cancercentre.mcgill.ca/research/index.php?searchword=oxygen&ordering=&searchphrase=all&option=com_search&lang=en

THEME - CANCER STEM CELLS & SIGNALLING

The study of stem cells is vitally important in biomedical research. The scientists in this unit study the signaling pathways between healthy and cancerous cells, and between cancerous tissues and tumors with their surroundings.

Stem cells are unspecialized cells that have the ability to divide indefinitely and to differentiate into any other cell type in the human body. Under normal conditions, these unique cells possess the properties of life-long regeneration, providing a human being with the means to replenish blood, skin, muscle and other cells throughout life. Understanding the signaling that controls the growth and differentiation properties of stem cells is of great importance.

A major aim of stem cell research is to understand the differentiation programs of stem cells and to ultimately use that knowledge to treat major diseases, such as Alzheimer’s, Parkinson’s, spinal chord injuries and heart disease. Many tumor types are thought to grow from a small population of cancerous cells that have ‘stem-like’ properties, allowing them to divide indefinitely. A major front in cancer research is to identify these cancer stem cells and design therapies that can target them specifically. 

The growth of both normal and cancer stem cells is intimately linked to their surrounding tissues and biochemical signals collectively referred to as the stem cell “niche”. Deciphering this communication system is critical to understanding how stem cells can regenerate tissues, as well as how they can develop into cancers.

The researchers of this unit focus on the biochemical signaling processes of both normal and cancer stem cells within their living surroundings, providing insights leading to new therapies in both tissue regeneration and novel forms of cancer treatment that target tumor stem cells.

http://cancercentre.mcgill.ca/research/index.php?searchword=oxygen&ordering=&searchphrase=all&option=com_search&lang=en