Clinical Studies:

Cardiovascular Diseases - (See also: Surgery and wound healing)

Cardiovascular Diseases - Ozone Therapy - 03

Biedunkiewicz, B.; L. Tylicki; T. Nieweglowski; S. Burakowski & B. Rutkowski, Clinical efficacy of ozonated autohemotherapy in hemodialyzed patients with intemittent claudication: An oxygen-controlled study. International Journal of Artificial Organs 27: 29-34, 2004.(abstract)

Bykov, Anatoly; Claudia Kontorshchikova & Elena Sycheva, The use of ozone in a complex treatment and its effect on functional potential of cardio-vascular system and on specific resistance in patients with ischemic hearth disease. In: Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001. (full text PDF)

Clavo, Bernardino; Luis Catala; Juan L. Pérez; Victor Rodríguez & Francisco Robaina, Ozone therapy on Celebral Blood Flow: A Preliminary Report. Evidence Based Complementary and Alternative Medicine 1(3): 315-319, 2004. (abstract, PDF).

Devesa, Evis.; Silvia Menéndez; Maria M. Rodríguez; Manuel Gómez; Josué Garcia; Ana Carballo & Wilfredo Diaz, Ozone therapy in ischemic cerebro-vascular disease. In: Ozone in Medicine: Proceedings of the 11th Ozone World Congress (Stamford, CT., International Ozone Association, Pan American Committee) M-4-10-M-4-18, 1993. (abstract)

Di Paolo, N.; V. Bocci; G. Garosi; E. Borelli; A. Bravi; A. Bruci; C. Aldinucci & L. Capotondo, Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report. International Journal of Artificial Organs 23: 131-141, 2000. (abstract).

Di Paolo, N.; V. Bocci; D. P. Salvo; F. Palasciano; M. Biagioli; S. Meini; F. Galli; I. Ciari; F. Maccari; F. Cappelletti; M. Di Paolo & E. Gaggiotti, Extracorporeal blood oxygenation and ozonation (EBOO): A controlled trial in patients with peripheral artery disease. International Journal of Artificial Organs 28(10): 1039-1050, 2005. (abstract)

Giunta, R.; A. Coppola; C. Luongo; A. Sammartino; S. Guastafierro. A. Grassia; L. Giunta; L.Mascolo; A. Tirelli & L. Coppola, Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissue in patients with peripheral occlusive arterial disease. Annals of Hematology 80: 745-748, 2001. (abstract)

Giunta, R.; C. Luongo; C. Vicario; A. Sammartino; M. A. Marfella; G. Esposito; A. Coppola; B. Lettieri & L. Coppola, Oxygen-ozone treatment improves p50 std value in patients with peropheral vascular disease [abstract]. Critical Care 3(Suppl 1.): 59-60, 1999.

Hernandez, Frank; Silvia Menéndez & Rolando Wong, Decrease of Blood Cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy. Free Radical Biology & Medicine 19: 115-119, 1995. (abstract)

Kraft, K.; E. Steinkamp; A. Sachinidis; S. Seewald & H. Vetter, Effect of autohemotherapy with ozone on cardiovascular risk factors in patients with mild hypertension. Perfusion 11: 216-219, 1998.

Kraft, K.; E. Stenkamp & H. Vetter, Influence of autohemotherapy with ozone on blood pressure and cardiovascular risk factors in patients with mild hypertension [abstract]. American Journal of Hypertension 8: 133A, 1995.

Luongo, M.; L. Ferrara; G. Giordano; F. Del Genio; V. Paolella; L. Mascolo; A. Sammartino & C. Luongo, Advanced dressings and oxygen-ozone therapy to treat ulcers in chronic obliterant peripheral arteriopathies (AOCP) [abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 45, 2003.

Maslennikov, O. V.; I. G. Sharov; I. P. Potekhina; N. G. Dushkina; N. A. Kryzhanovskaia; N. O. Maslennikova; V. F. Bolgov; E. E. Pavlovskaia; L. V. Zheglova & S. F. Chalkina, [Effect of ozone therapy on hemostatic changes in patients with vascular atherosclerosis]. Klinicheskaia meditsina 75(10): 35-37, 1997. [Written in Russian] (abstract)

Menéndez, Silvia; José I. Fernández; José Turrent & Miguel J. Colmanero, La ozonoterapia en pacientes con neuroangiopatía diabética. Revista CENIC Ciencias Biológicas 29: 165-168, 1998.

Ponomarenko, G. N.; A. Iu. Tishakov; L. L. Bobrov; M. M. Odinak; A. N. Bitsadze & S. A.Kotel'nikov. Ozone baths in santorum-spa treatment of patients with ischemic heart disease. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury (2001 Jan-Feb) (1) 6-8.
[Written in Russian]

Rodríguez, María M.; Josué R. García; Silvia Menéndez; Evis Devesa & Sofía Valverde, Ozonoterapia en la enfermedad celebro-vascular isquémica. Revista CENIC Ciencias Biológicas 29: 145-148, 1998. (abstract)

Romero, A.; S. Menéndez; M. Gómez; W. Díaz & A. Carballo, La ozonoterapia en la aterosclerosis obliterante. Revista CENIC Ciencias Biológicas 20(1-3): 70-76, 1989.

Romero, Alexie; Silvia Menéndez; Manuel Gómez & Júan Ley, La ozonoterapia en la claudicacion intermitente de evolucion desfavorable. Revista Cubana de Cirugia 28(6): 543-548, 1989.

Romero, A.; R. Blanco; S. Menéndez; M. Gómez & J. Ley, Ateroesclerosis obliterante y ozonoterapia. Administración por diferentes vías. Angiología 45: 177-179, 1993. (abstract in english)

Tafil-Klawe, Malgorzata; Alina Wozniak; Tomasz Drewa; Irena Ponikowska; Joanna Drewa; Gerard Drewa; Konrad Wlodarczyk; Dorota Olszewska; Jacek Klawe & Roza Kozlowska, Ozone therapy and the activity of selected lysosomal enzymes in blood serum of patients
with lower limb ischaemia associated with obliterative atheromatosis. Medical Science Monitor 8: CR520-CR525, 2002. (abstract)

Tattoni, G. & A. Franchina, Osservazioni sull'eficacia di un trattamento balneoterapico ozonizzato in pazienti affetti da vasculopatie periferiche. Minerva Cardioangiologica 25: 745-748, 1977. (abstract)

Tylicki, L.; T. Nieweglowski; B. Biedunkiewicz; B. Burakowski & B. Rutkowski, Benefical clinical effects of ozonated autohemotherapy in chronically dialysed patients with atherosclerotic ischemia of the lower limbs - pilot study. International Journal of Artificial Organs 24: 79-82, 2001. (abstract)

Tylicki, L.; T. Nieweglowski; B. Biedunkiewicz; A. Chamienia; A. Debska-Slizien; E. Aleksandrowicz; W. Lysiak-Szydlowska & B. Rutkowski, The influence of ozonatedautohemotherapy on oxidative stress in hemodialyzed patients with atherosclerotic ischemia of lower limbs. International Journal of Artificial Organs 26: 297-303, 2003. (abstract)

Tylicki, Leszek; Bogdan Biedunkiewicz; Tomasz Nieweglowski; Anrzej Chamenia; Alicja Slizien; Joanna Luty; Wieslawa Lysiak-Szydlowska & Boleslaw Rutkowski, Ozonated Autohemotherapy in Patients on Maintenance Hemodialysis: Influence on Lipid Profile and Endothelium. Artificial Organs 28: 234-236, 2004. (abstract)

Verrazzo, G.; L. Coppola; C. Luongo; A. Sammartino; R. Giunta; A. Grassia; R. Ragone & A. Tirelli, Hyperbaric oxygen, ozone therapy, and rheologic parameters of blood in patients with peripheral occlusive arterial disease. Undersea & Hyperbaric Medicine 22: 17-22, 1995. (abstract)

Cardiovascular Diseases - Hydrogen Peroxide Therapy - H2O2

Finney, James W.; Bruce E. Jay; George J. Race; Harold C. Urschel; John T. Mallams & George A. Balla, Removal of cholesterol and other lipids from experimental animal and human atheromatous arteries by dilute hydrogen peroxide. Angiology 17: 223-228, 1966. (PubMed)

Lebedev, L. V.; A. O. Levin; M. P. Romankova; K. G. Rychkova & I. V. Arsen'eva, [Regional oxygenation in the treatment of severe destructive forms of occlusive arterial diseases of the limbs]. Vestnik khirurgii imeni I. I. Grekova 132(3): 85-88, 1984. [Written in Russian] (abstract)

Shidlovski, V. A., [Blood oxygenation in patients with arterial occlusive diseases of the lower limbs]. Vestnik khirurgii imeni I. I. Grekova 135(10): 52-53, 1985. [Written in Russian] (abstract)

Urschel, Harold C.; James W. Finney; George A. Balla & John T. Mallams, Regional Oxygenation of the Ischemic Myocardium with Hydrogen Peroxide. Surgical Forum 15: 273-274, 1964. (PubMed)

Urschel, H. C.; A. R. Morales; J. W. Finney; G. A. Balla; G. J. Race & J. T. Mallams, Cardiac Resuscitation with Hydrogen Peroxide. Annals of Thoracic Surgery 2: 665-682, 1966. (PubMed)

Urschel, Harold C., Cardiovascular Effects of Hydrogen Peroxide: Current Status. Diseases of the Chest 51: 180-192, 1967. (PubMed)

Surgery and Wound Healing - Ozone Therapy - 03

Alleman, Von R., Zur Ozonbehandlung großer, schlecht heilender Wunden. Zentralblatt für Chirurgie 1934 (25): 1461-1464, 1934.

Aubourg, Paul, L'ozone en Chirurgie. Memoires de l'academie de Chirurgie 65: 1183-1192, 1939.

Anichini, R.; A. De Bellis; L. Butelli; M. Gioffredi; R. Gori; R. Picciafuochi; S. Nannelli; R. Rossetti & L. Alviggi, Ozone-therapy in treatment of diabetic foot ulcers: a suggestive approach in wound bed preparation [abstract]. European Journal of Clinical Investigation 33 (1.suppl): 46-47, 2003.

Bearzatto, A.; F. Vaiano & M. Franzini, O2–O3 -therapy of non-healing foot and leg ulcers in diabetic patients. European Journal of Clinical Investigation 33 (1. suppl.): 44, 2003.

Bulynin, V. I.; A. I. Ermakova; A. A: Glukhov & I. P. Mozhurov, [Wound treatment using the flow of an ozonized solution under high pressure]. Khirurgiia (1998), (8), 23-24. [Written in Russian] (abstract)

Calderon, Noam; Teddy Kaufman; Leonid Bryzgalin & Munir Awad, The intensive care of lower limb diabetic wounds: Our 5 years experience in 121 patients treated topically with ozone as an adjunctive agent. In (CD-ROM): Ozone Seminar Congress, European Cooperation of the Medical Ozone Societies, May 23rd -May 25th, Munich 2003.

De las Cajigas, T.; V. Bastard; S. Menéndez; M. Gómez; & L. Eng, El aceite ozonizado en infecciones de la piel y su aplicacion en el consultorio del medico de la familia. Revista CENIC Ciencias Biológicas 20(1-3): 81-84, 1989.

De Monte, Amato; Hoyte van der Zee & Velio Bocci, Major ozonated Autohemotherapy in Chronic Limb Ischemia with Ulcerations. Journal of Alternative and Complementary Medicine 11: 363-367, 2005. (abstract)

Diaz, Orestes & Roberto Castellanos, Ozonoterapia en úlceras flebostáticas. Revista Cubana de Cirugía 40: 123-129, 2001. (full text PDF)

Driban, N., Elawox Puder, ein hochprozentigen Wasserstoffsuperoxyd-Puder, in der Ulcus crurisBehandlung. Fortschritte der Medizin 90(13): 515-516, 1972. (PubMed)

Gallucci, Cristiano; Alessandro Agrillo; Giorgio Iannetti; Robert Foá & Maria Teresa Petrucci, Possible Role of Ozone Therapy in Treatment of Osteonecrosis of the Jaws in Multiple Myeloma Patients [abstract]. Blood 106(ASH abstracts): Abstract 4060, 2005.

Guyot, René & C. -M. Roques, L'eau de mer isotonique ozonisée pour le pansement des plaies de guerre. Un nouvel ozoneur. Comptes rendus des séances de la Société de biologie et de ses filiales 79: 289-290, 1916. (full text PDF)

Hančević, Janko; Josip Turčić; Tonisav Antoljak & Mirko Livaković, Ozone Treatment of War Injuries. Croatian Medical Journal 33(War Suppl. 2): 208-210, 1992. (abstract)

Jordan, Liz; Kinta Beaver & Sharon Foy, Ozone treatment for radiotherapy skin reactions: Is there an evidence base for practice? European Journal of Oncology Nursing 6: 220-227, 2002. (abstract)

Kavkalo, D. N., [Principles of complex treatment of infection in emergency surgery]. Klinicheskaia khirurgia (1991), (4), 47-49. [Written in Russian] (abstract)

Kawalski, H.; J. Sondej & E. Cierpiol-Tracz, The use of ozonotherapy in the nose correction operations. Acta Chirurgiae Plasticae 34: 182-184, 1992. (abstract)

Kudriavtsev, E. P.; S. I. Miroshin; S. V. Semenov; A. S. Snigorenko & I. A. Sidorovich, [Ozone therapy of diffuse peritonitis in the early postoperative period]. Khirurgiia (1997), (3), 36-41. [Written in Russian]. (abstract)

Laberko, L. A.; N. A. Kuznetsov; L. S. Aronov; G. V. Rodoman; A. T. Brontvein; T. V. Semenova& V. V. Fomin, [Correction of enteral insufficiency syndrome in general peritonitis]. Khirurgiia no.9, 25-28, 2004. [Written in Russian] (abstract)

Lipatov, K. V.; M. A. Sopromadze; A. B. Shekhter; T. G. Rudenko & A. Yu Emelianov, [Ozoneultrasonic therapy in the treatment of purulent wounds]. Khirurgiia (Mosk). 2002;(1):36-39. [Written in Russian] (abstract)

Malanchuk, V. A.; V. D. Tsidelko; A. V. Kopchak & A. I. Kuzmichev, [Ozonotherapy in stomatology and maxillo-facial surgery]. Ukrainskij Mediskij Tsasopis No. 6(20): 61-68, 2000. [Written in Russian] (abstract)

Martínez-Sánchez, Gregorio; Saeid M. Al-Dalain; Silvia Menéndez; Lamberto Re; Attilia Giuliani; Eduardo Candelario-Jalil; Hector Álvarez; José Ignacio Fernández-Montequin & Olga Sonia León, Therapeutic efficacy of ozone in patients with diabetic foot. European Journal of
Pharmacology 523(1-3): 151-161, 2005. (abstract)

Martiyanov, S. G., [Long-term intra-arterial therapy in complex treatment of anaerobic gangrene]. Khirurgiia 1976(6): 72-74. [Written in Russian] (PubMed)

Matsumoto, Akiyo; Shotaro Sakurai; Nariko Shinriki; Shigeru Suzuki & Toshiaki Miura, Therapeutic Effects of Ozonized Olive Oil in the Treatment of Intractable Fistula and Wound after Surgical Operation. In: Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001. ( full text PDF)

Parkhisenko, Iu A. & A. A. Glukhov, [Use of ozone therapy and hydro-pressure technologies in complex intensive therapy of surgical sepsis]. Khirurgiia (2001), (4), 55-8. [Written in Russian]. (abstract)

Parmenov, V. I., [Arterial blood pumping in terminal conditions and state of clinical death in patients with abdominal wounds, Vestnik Khirurgii Imeni I I Grekova 91(Sept.): 95-96, 1963.(PubMed)

Payr, E., Ueber Ozonbehandlung in der Chirurgie. Münchener Medizinische Wochenschrift 82: 857-860, 1935.

Rovira Dupláa, G. & N. Galindo Planas, La Ozonoterapia en el tratamiento de las úlceras crónicas de las extremidades inferiores. Angiología 43(2): 47-50, 1991. (PubMed)

Quinones, M.; S. Menéndez; M. Gómez; W. Díaz; L. Eng & C. Vecino, Ozonoterapia en el tratamiento de las ulceras de miembros inferiores causadas por insufiencia venosa cronica. Revista CENIC Ciencias Biológicas 20(1-3): 76-81, 1989.

Sader, R.; H. -F. Zeilhofer & H. Deppe, Ozontherapie Chronischer Wundheilungsstörungen im bestrahlten Kiefer. Deutsche Zeitschrift für Mund-, Kiefer- und Gesichtschirurgie 20: 60-64, 1996. (abstract)

Stroker, George, The Surgical Uses of Ozone. Lancet II (Oct. 21): 712, 1916. (full text PDF)

Stroker, George, The Surgical Uses of Ozone. Lancet I (May 26): 797, 1917. (full text PDF)

Thwaites, M., Ozone Healing. Medical Journal of Australia, May 14: I: 757-758, 1977. (PubMed)

Turčić, J.; J, Hančević; T. Antoljak; R. Žic & I. Alfirević, Effects of ozone on how well splitthickness skin grafts according to Thiersch take in war wounds: Results of prospective study. Langenbecks Archiv für Chirurgie 380(3): 144-148, 1995. (abstract)

Velasco, N.; S. Menéndez; J. F. Montequin; M. Gómez; B. Lima; J. A. Montalvo; W. Díaz & L.Eng, Valor de ozonoterapia en el tratamiento del pie diabetico neuroinfeccioso. Revista CENIC Ciencias Biológicas 20(1-3): 64-70, 1989.

Wolff, Albert, Eine medizinische verwendbarkeit des ozons. Deutsche Medizinische Wochenschrift (1915), 311-312, 1915. (full text PDF)

Wolff, Albert, Ozon in der Wundbehandlung. Berliner Klinische Wochenschrift 1920 nr. 33, 785-786, 1920. (full text PDF)

Wong, R., J. Delgado; S. Menéndez & M. Gómez, Ozonoterapia y ulcera lingual. Revista CENIC Ciencias Biológicas 20(1-3): 103-104, 1989.

Zhebelenko, G. I.; i. T. Vasil'ev; G. A. Iarovaia; R. B. Muladze & T. D. Kantariia, [Status of the kallikrein-kinin systems and level of antiproteinase potential during postoperative treatmentof various forms of peritonitis]. Voprosy meditsinskoi khimii 41(1): 49-53, 1995. [Written in Russian] (abstract)

Surgery and Wound Healing - Hydrogen Peroxide Therapy - H2O2

Balla, G. A.; J. W. Finney; B. L. Aronoff; D. L. Byrd; G. J. Race; J. T. Mallams & G. Davis, Use of Intra-arterial Hydrogen Peroxide to Promote Wound Healing. American Journal of Surgery 108: 621-629, 1964. (PubMed)

Ophthalmology / Eye Diseases - Ozone Therapy - O3

Berson, Eliot; Juancho F. C. Remulla; Bernard Rosner; Michael A. Sandberg & Carol WiegelDiFranco, Evaluation of Patients With Retinitis Pigmentosa Receiving Electric Stimulation, Ozonated blood, and Ocular Surgery in Cuba. Archives of Ophthalmology 114: 560-563, 1996. (abstract)

Copello, Mirtha; Frank Eguía; Silvia Menéndez & Niusdalys Menéndez, Ozone therapy in patients with Retinitis Pigmentosa. Ozone: Science & Engineering 25: 223-232, 2003. (abstract)

Ferrer, Lourdes A.; Daisy Santos; Silvia Menéndez & Zoila Perez, Ozonoterapia y magnetoterapia: nuevos métodos en la rahabilitación del paciente con glaucoma crónico simple. Revista Cubana de Oftalmologia Vol. 9(2), 1996. (full text)

Ferrer Mahojo, Lourdes A.; Francisco Varela Cadalso & Idalmis Fernández Mulens, Mecanismo del acción local de la ozonoterapia y su combinación con el campo magnético en pacientes con glaucoma primario de ángulo abierto estado inicial. Revista Cubana de Oftalmologia
Vol. 17(2), 2004. (full text)

Ibáñes, Mariela; Armando Rodríguez; Lourdes A. Ferrer & Gloria Fernández, Estudio comparativo de dos métodos terapéuticos en el glaucoma crónico simple. Revista Cubana de Oftalmologia, Vol. 9. No. 2., 1996. (full text)

Iuzhakov, A. M,; V. P. Bykov; I. D. Ziurniaeva & M. G. Gogodze, [New prospects in the treatment of intraocular infection]. Vestnik oftalmologii (2000 Jan-Feb), 116(2), 20-22 [Written in Russian]. (abstract)

Marmer, Robert H. & Susan Parks, Ozone Treatment in Retinitis Pigmentosa: Effect on Color Perception and Blood Gasses. Annals of Ophthalmology 30: 161-163, 1998. (full text)

Marmer, Robert H. & Susan Parks, Ozone Treatment in Retinitis Pigmentosa: Effect on Photo Stress and Contrast Sensitivity. Annals of Ophthalmology 30: 164-166, 1998. (full text)

Menéndez, S.; O. Peláez; M. Gómez; M. Copello; M. Mendoza & W. Díaz, Aplicación de la ozonoterapia en la retinosis pigmentaria. Revista CENIC Ciencias Biológicas 20(1-3): 84-90, 1989.

Menéndez, S.; O. Peláez; M. Gómez; M. Copello; M. Mendoza; W. Díaz & A. Carballo, La ozonoterapia en el campo de la oftalmologia. Revista CENIC Ciencias Biológicas 20(1-3): 91-93, 1989.

Neroev, V. V.; M. V. Zueva; I. V. Tsapenko & A. T. Khandzhian, [Effects of ozone therapy on the functional activity of the retina in patients with involutional central chorioretinal dystrophy]. Vestnik oftalmologii (2003 Nov-Dec), 119(6), 18-21. [Written in Russian]. (abstract)

Riva Sanseverino, E.; R. A. Meduri; A. Pizzino; M. Prantera & E. Martini, Effects of oxygen-ozone therapy on age-related degenerative retinal maculopathy. Panminerva Medica 32: 77-84, 1990. (abstract)

Santiesteban, R.; S. Menéndez; M. Gómez & M. Francisco, ozonoterapia en la atrofia optica. Revista CENIC Ciencias Biológicas 20(1-3): 93-99, 1989.

Santiesteban, R.; S. Menéndez; M. Francisco & S. Luis, Ozone therapy in the optic nerve dysfunction. In: Ozone in Medicine: Proceedings of the 11th Ozone World Congress(Stamford, CT., International Ozone Association, Pan American Committee) M-4-1-M-4-9, 1993. (abstract)

Dermatology / Skin Diseases - Ozone Therapy - O3

Amtmann, V., Ionozon-Bestrahlungen (Eine Bereicherung der dermatologischen Therapiemöglichkeiten). Zeitschrift fur Haut- und Geschlenchtskrankheiten 42: 723-728, 1967. (PubMed)

Christensen, Ole B. & Siw Anehus, Hydrogen Peroxide Cream: An Alternative to Topical Antibiotics in the Treatment of Impetigo Contagiosa. Acta Dermato-Venereologica 74: 460- 462, 1994. (abstract)

Church, Linda, Ionozone Therapy for Skin Lesions in Elderly Patients. Physiotherapy 66: 50-51, 1980. (PubMed)

Dolphin, Shirley & Myrtle Walker, Healing Accelerated by Ionozone Therapy. Physiotherapy 65: 81-82, 1979. (PubMed)

Falcón, Leopoldina; Silvia Menéndez; Ramón Daniel;Enrique Garbayo; Sonia Moya & Marlene Abreu, Aceite ozonizado en Dermatología. Experiencia de 9 años. Revista CENIC Ciencias Biológicas 29: 192-195, 1998. (abstract)

Falcón, Leopoldina; Ramón Daniel; Silvia Menéndez; Niurka Landa & Sonia Moya, Solución para la epidermofitosis de los pies en integrantes de las fuerzas armadas revolucionarias. Revista Cubana de Medicina Militar 29: 98-102, 2000. (full text PDF)

Gloor, M. & B. A. Lipphardt, Untersuchungen zur Ozontherapie der Akne vulgaris. Zeitschrift fur Hautkrankheiten 51: 97-101, 1976. (abstract)

Kief, H., Die Behandlung der Neurodermatitis mit autohomologer Immuntherapie (AHIT). Erfahrungsheilkunde 38(1): 9-18, 1989. (abstract)

Kief, H. & H. W. Christ, Psoriasis-Therapie mit AHIT. Erfahrungsheilkunde 42(9): 449-453, 1993. (abstract)

Kosheleva, Irina V.; Oleg L. Ivanov & Alexander G. Kulikov, Various Modes of Ozone-Oxygen Gas Mixture Application in Patients with Eczema. In: Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001.

Kosheleva, I. V, & A. G. Kulikov, [Effectiveness of complex therapy of eczema patients with the use of various methods of ozone therapy]. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury (2001 Sep-Oct), (5), 40-2. [Written in Russian].(PubMed)

Krivatkin, Sergei L., The Experience of Ozonotherapy in dermatovenereological Dispensary. Preliminary Data. In: Ozone in Medicine: Proceedings of the 11th Ozone World Congress (Stamford, CT., Int Ozone Association, Pan American Committee) M-3-5-M-3-11, 1993.

Krivatkin, Sergey L. & E. V. Krivatkina, Photo-, phyto- and frostbite- provoked cases of contact dermatitis cured with O3 [abstract]. Contact Dermatitis 50(3): 191, 2004.

Krivatkin, Sergej & E. V. Krivatkina, Ozontherapie bei dermatologischen Erkrankungen. Erfahrungsheilkunde 49(11): 736-739, 2000. (abstract)

Manok, M., On a Simple and Painless Treatment of Warts. Hautarzt 12: 425, 1961. (PubMed)

Menéndez, S.; L. Falcón; D. R. Simón & N. Landa, Efficacy of ozonized sunflower oil in the treatment of tinea pedis. Mycoses 45: 329-332, 2002. (abstract)

Protsenko, T. V. & L. V. Kutsenko, [The experience of ozonotherapy using in the patients with allergic dermatoses treatment]. Dermatologija no.4, 34-37, 2003. (full text in Russian)

Riva Sanseverino, E.; P. Castellacci; C. Misciali; P. Borrello & N. Venturo, Effects of ozonized autohaemotherapy on human hair cycle. Panminerva Medica 37: 129-132, 1995. (abstract)

Sharlit, Herman, The use of ozonides in dermatology. New York State Journal of Medicine (Oct. 1, 1946) 2147-2149.

Shpektorova, R. A., [Ozone therapy of some skin diseases]. Vestnik dermatologii i venerologii 38: 44-6. 1964. [Written in Russian] (PubMed)

Smirnov, A. V.; S. L. Krivatkin; M. Yu. Pestova; E. V. Krivatkina & O. A. Ivanova, Ozonetherapy in localized scleroderma [abstract]. Journal of the European Academy of Dermatology and Venereology 5: 158, 1995.

Orthopedic Problems and Other Bone and Joint Disorders

Andreula, C.; M. Leonardi & M. Bonetti, Chemodiscolysis and periradicular and periganglionic infiltration with oxygen-ozone in disc herniation. [abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 46, 2003.

Alexandre, A.; L. Coró; A. Azuelos; H. Salgado; M. Murga; F. Marin & H. Giocoli, Intradiscal injection of oxygen-ozone gas mixture for treatment of cervical disc herniations. Acta Neurochirurgica Supplement 92: 79-82, 2005. (abstract)

Andreula, Cosma F.; Luigi Simonetti; Fabio de Santis; Raffaele Agati; Renata Ricci & Marco Leonardi, Minimally Invasive Oxygen-Ozone Therapy for Lumbar Disk Herniation. American Journal of Neuroradiology 24: 996-1000, 2003. (Abstract/full text)

Apuzzo, D.; M. Franzini; L. Di Lucente; M. C. Gioia; A. Cerasa; U. Sabatini & A. CastriotaScanderberg, Combined effect of O2/O3 and GPR in treatment of lumbar disc herniation: anatomical, clinical, and patient-self-report evaluation [abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 46, 2003.

Bolgaev, A. B.; S. D. Mad'iarov & S. B. Makhmudov. [Treatment of chronic leptomeningitis (arachnoiditis) by administration of ozone into the subarachnoid space]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (1977), 77(2), 188-90. [Written in Russian]. (abstract)

Bonetti, M.; A. Fontana & F. Albertini, CT-guided oxygen-ozone treatment for first degree spondylolisthesis and spondylolysis. Acta Neurochirurgica. Supplement 92: 87-92, 2005. (abstract)

Bonetti, M; B. Cotticelli; F. Albertini; L. Valdenassi & P. Richelmi, CT-guided intraforaminal oxygen-ozone therapy in lumbar disc herniation [abstract]. European Journal of Clinical Investigation 33 (1. suppl.) 43-44, 2003.

Bonetti, Matteo; Alessandro Fontana; Biagio Cotticelli; Giorgia Dalla Volta; Massimiliano Guindani & Marco Leonardi, Intraforaminal O2 -O3 versus Periradicular Steroidal Infiltrations in Lower Back Pain: Randomized Controlled Study. American Journal of Neuroradiology 26: 996-1000, 2005. (abstract / full text PDF)

Buric, J. & R. Molino Lova, Ozone chemonucleolysis in non-contained lumbar disc herniations: a pilot study with 12 months follow-up. Acta Neurochirurgica. Supplement 92: 93-97, 2005. (abstract)

Ceballos, A.; R. Balmaseda; R. Wong; S. Menéndez & M. Gómez, Tratamiento de la osteoartritis con ozono. Revista CENIC Ciencias Biológicas 20(1-3): 151-153, 1989.

Delgado Rifá; Eraclio & Juan Vicente Quesada Musa, Ozonoterapia intraarticular en la enfermedad artrósica de rodilla. Revista Cubana de Ortopedia y Traumatología 19(1): 23-28, 2005. (full text PDF)

D´Erme, M.; A. Scarchilli; A. M. Artale & Lasagni M. Pasquali, [Ozone therapy in lumbar sciatic pain.] Radiologia Medica 95: 21-24, 1998. (Article written in Italian) (abstract)

Escarpanter; Julio César, Una solución para exposiciones óseas postraumáticas: asociación de injerto de epiplon mayor con ozonoterapia. Revista Cubana de Investigaciones Biomédicas Vol.15. No. 2., 1996. (full text)

Escarpanter; Julio C., Odalys Valdés; Ramón Sánchez; Yanet López & Celso López, Resultados terapéuticos en la osteoartritis de la rodilla con infiltraciones de ozono. Revista Cubana de Investigaciones Biomédicas 16: 124-132, 1997. (full text)

Escarpanter Buliés, Julio C.; Oxígeno-ozonoterapia como coadyuvante en el tratamiento de las infecciones óseas. Revista Cubana de Ortopedia y Traumatología 19(1): 4-9, 2005. (full text PDF)

Fahmy, Z., Immunological effect of ozone (O3/O2) in rheumatic diseases. In: Ozone in Medicine: Proceedings of the 11th Ozone World Congress (Stamford, CT., International Ozone Association, Pan American Committee) M-3: 22-30, 1993.

Gjonovic, A.; E. Montimara; T. Girotto; P. Richelmi & L. Valdenassi, Oxygen-ozone therapy in disc-root compression pain syndrome: comparison with other methods [abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 44, 2003.

Mascolo, L.; A. Sammartino; M. Luongo; V. Villani; C. Cipollaro & C. Luongo, Postural diagnosis importance in the root-disc conflict pathology [abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 45, 2003.

Mattozzi, I.; Gp. Laurini; G. Muzzi; M. Franzini & A. Bigiotti, Intradiscal epidural injection with oxygen-ozone for the treatment of low back pain. Comparison and evaluation with other techniques and rehabilitation and return to work [abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 45, 2003.

Menéndez; F.; G. Díaz & S. Menéndez, Ozonoterapia en la artritis reumatoidea. Revista CENIC Ciencias Biológicas 20(1-3): 144-151, 1989.

Monticone, M.; A. Barbarino; R. Garri; L. Valdenassi; P. Richelmi; F. Bertè & A. Moschi, Spinal segmental stabilization and oxygen-ozone therapy for lumbar discal hernia: controlled, multicentric, randomized study - preliminary results [abstract]. European Journal of Clinical Investigation 33 (1. suppl.): 44, 2003.

Muto, M.; C. Andreula & M. Leonardi, Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection. Journal of Neuroradiology 31: 183-189, 2004. (abstract)

Paradiso, R. & A. Alexandre, The different outcomes of patients with disc herniation treated either by microdiscectomy, or by intradiscal ozone injection. Acta Neurochirurgica Supplement 92: 139-142, 2005. (abstract)

Pribluda, Samuel, Tratamiento de las lumbociaticas y otros sindromes similares con el ozono subcutaneo. Semana Medica 123(26): 1026-1028, 1963.(PubMed)

Riva Sanseverino, E., Intensive medical and physical treatment of osteoporosis with the aid of oxygen-ozone therapy. Europa Medicophysica 24: 199-206, 1988. (abstract)

Riva Sanseverino, E., Knee-joint disorders treated by oxygen-ozone therapy. Europa Medicophysica 25: 163-170, 1989. (abstract)

Torri, G.; A. Della Grazia & C. Casadei, Clinical experience in the treatment of lumbar disk disease, with a cycle of lumbar muscles injections of an oxygen + ozone mixture. International Journal of Medicine, Biology and the Environment 27: 177-183, 1999.

Torri, G. & F. Vaiano, Clinical experience in the treatment of lumbar and cervical disc disease, knee arthritis and ‘frozen’ shoulder, by injection of an oxygen-ozone mixture [abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 46, 2003.

Valdenassi, L.; G. Nardelli; P. Richelmi & F. Bertè, Follow-up disc-root compression and postsurgical radiculopathies with paravertebral oxygen-ozone [abstract]. European Journal of Clinical Investigation 33 (1. suppl.): 44-45, 2003.

Zimran, Ari; Gerhard Wasser; Nathan Cherny; Josef Dayan; Eyal Attias & Deborah Elstein, Autohemotherapy with ozone for patients with Gaucher disease and severe skeletal involvement. Pain Clinic 13: 223-226, 2002. (abstract)

Cancer / Oncology

Ambesi, G.; C. Nervi; M. Cortese & C. Casale, La radioterapia dei tumori in condizioni di iperrossigenazione regionale. Radiologia Medica 55(3): 193-206, 1969. (summary) Aronoff, B L; G. A.Balla; J. W. Finney; R. E. Collier & J. T. Mallams, Regional oxygenation in the diagnosis and management of intra-abdominal and retroperitoneal neoplasms. Cancer 18: 1244-1250, 1965. (PubMed)

Biachini, G.; G. Salgarello; T. Mennini & G. Lorini, Infusione intra-arteriosa di perossido di idrogeno nella radioterapia dei tumori maligni. Radiologia Medica 55(3): 207-225, 1969.

Borrego, Luis; Luis L. Borrero; Elena Díaz; Silvia Menéndez; Luis R. Borrego & René A. Borrego, Ozono más cobaltoterapia en pacientes con adenocarcinoma prostático. Revista CENIC Ciencias Biológicas 29: 137-140, 1998. (abstract)

Chasin, W. D.; C. C. Gross; C. C. Wang & D. Miller, Hydrogen Peroxide and Irradiation of Tumors. Archives of Otolaryngology 85: 151-155, 1967. (PubMed)

Clavo, Bernardino; Juan L. Perez; Laura Lopez; Gerardo Suarez; Marta Lloret; Victor Rodriguez; David Macias; Maite Santana; María A. Hernández; Roberto Martín-Oliva & Francisco Robaina, Ozone Therapy for Tumor Oxygenation: a Pilot Study. Evidence-based Complementary and Alternative Medicine 1: 93-98, 2004. (full text PDF)

Clavo, Bernardino; Ana Ruiz; Marta Lloret; Laura López; Gerardo Suárez; David Macías; Victor Rodríguez; Maria A. Hernández; Roberto Martín-Oliva; Santiago Quintero; José M. Cuyas & Francisco Robaina, Adjuvant Ozonetherapy in Advanced Head and Neck Tumors: A Comparative Study. Evidence-based Complementary and Alternative Medicine 1(3): 321- 325, 2004 (abstract, full text PDF).

Corgill, D. A., Arterial Anticancer Drug Infusion Therapy. Laryngoscope 72: 1158-1178, 1962. (PubMed)

Corgill, D. A., Intra-arterial Hydrogen Peroxide and Irradiation for Tumors ot the Head and Neck: A Preliminary Report. Transactions, American Academy of Ophthalmology and Otolaryngology 67: 790-800, 1963. (PubMed)

Dall'Aglio, Roberto; Demetrio Franchini; Roberto Buzzoni; Paolo Scrollavezza & Antonio Ubaldi, Ozone and breast cancer serum markers. In: Ozone in Medicine: Proceedings of the 11th Ozone World Congress (Stamford, CT., International Ozone Association, Pan American Committee) M-4: 32-35, 1993.

Enzelsberger, H.; M. Metka & H. Salzer, Der Einfluß von parenteraler OzonSauerstoff-GemischApplikation auf die Konzentration von Immunoglobulin (IgA, IgG, IgM), von Vitamin A und die Aktivität von Lysozym bei Patientinnen mit Zervixkarzinom. Geburtshilfe und Frauenheilkunde 47: 843-845, 1987. (abstract)

Gretchkanev, Guennadi O.; Tatyana S. Kachalina; E. Yu. Palkina; Claudia N. Kontorchikova & ElHassoun Husein, Medical Ozone for Prophylaxis and Treatment of Complications associated by Chemotherapy of Ovary Cancer. In: Proceedings of the 15th Ozone World Congress, 11th
- 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001. (full text PDF)

Grechkanev G. O., [Role of ozone therapy in prevention and treatment of complications of drug therapy for ovarian cancer]. Akusherstvo i Ginekologiya №4, 57-58, 2002. [Written in Russian]

Hernuss, P.; E. Müller-Tyl & J. Dimopoulos, Ozon-Sauerstoff-Injektionsbehandlung in der gynäkologischen Strahlentherapie. Strahlentherapie 148: 242-245, 1974. (abstract)

Hernuss, P.; E. Müller-Tyl & L. Vicke, Ozon und gynakologische Strahlentherapie. Strahlentherapie 150: 493-499, 1975. (abstract)

Jacobson, Judith S.; Victor R. Grann; Michael A. Gnatt; Hanina Hibshoosh; John H. M. Austin; William S. Millar & Alfred I. Neugut, Cancer Outcomes at the Hufeland (Complementary/Alternative Medicine) Klinik: A. Best-Case Series Review. Integrative Cancer Therapies 4(2): 156-167, 2005. (abstract)

Kief, Horst, The treatment of malignant diseases with AHIT. In: Ozone in Medicine: Proceedings of the 11th Ozone World Congress (Stamford, CT., International Ozone Association, Pan American Committee) M-4: 26-31, 1993. (abstract)

Kontorschikova, Claudia N.; Anna V. Alaysova & Igor G. Terentiev, Ozonetherapy in a Complex Treatment of Breast Cancer. In: Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd,
Ealing, London, UK, 2001. (abstract)

Mallams, John T.; G. A. Balla & J. W. Finney, Regional intra-arterial hydrogen peroxide infusion
and irradiation in the treatment of head and neck malignancies: A progress report.
Transactions, American Academy of Ophthalmology and Otolaryngology 67: 546-553., 1963.
(PubMed)Mallams, J. T.; G. A.Balla; J. W. Finney & B. L. Aronoff, Regional Oxygenation and Irradiation:
Head and Neck. Archives of Otolaryngology 79: 154-159, 1964. (PubMed)
Mallams, J. T.; G. A. Balla & J. W. Finney, Regional Oxygenation and Radiation Therapy: Current
Status. American Journal of Roentgenology, Radium Therapy and Nuclear Medicine 93: 160-
169, 1965. (PubMed)
Mallams, J. T.; G. A. Balla & J. W. Finney, Regional oxygenation and irradiation in the treatment
of malignant tumors. Progress in Clinical Cancer 1: 137, 1965. (PubMed)
Marshall-Manifold, Thomas, Three case reports on the holistic approach to patients with neoplasm
including the use of medical ozone. In: Proceedings of the 15th Ozone World Congress, 11th
- 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia
Ltd, Ealing, London, UK, 2001. (PDF)
Müller-Tyl, E.; H. Salzer; J. Washüttl & F. Wurst, Ozon-Sauerstoff-Therapie bei gynäkologischen
Karzinomen. Fortschritte der Medizin 97: 451-454, 1979. (abstract)
Nervi, Carlo; Carlo Casale & Massimo Cortese, L’iperossigenazione regionale: un importante
fattore di potenziamento della chemioterapia antineoplastica. Tumori 55: 153-160, 1969.
(summary)
Nervi, C.; C. Casale & M. Cortese, Potenziamento dell'attivita' terapeutica dei farmaci antiblastici
per mezzo della iperrossigenazione regionale. Policlinico [Med] 76(6): 335-342, 1969.
(summary)
Potanin, V.P.; V.M. Belopukhov; R.M. Taziev; M.Kh. Mustafin & I.D. Khalimov, [Ozonotherapy
in the early postoperative period in the surgical treatment of the lung cancer.] Kazanskij
medicinskij zurnal No. 4, 263-265, 2000. [Written in Russian] (abstract)
Sasaki, Hiroshi; Tadao Wakutani; Sikayuki Oda & Yasuo Yamasaki, Application of Hydrogen
Peroxide Infusion to Maxillary Cancer. Yanago Acta Medica 11: 141-149, 1967. (PubMed)
Yollick, Bernard L. & Donald A. Corgill, Regional Chemotherapy of Head and Neck Tumors By
Intra-Arterial Infusion Techniques. Texas State Journal of Medicine 59: 423-429, 1963.
(PubMed)
Studies on the tumour scanning with hydrogen peroxide infusions
Bonte, Frederick J.; Michael Howett; Ben Carter; Alvin J. Greenberg & Karl T. Dockray,
Experimental Tumor Scanning with Intraaterial Hydrogen Peroxide and 131I HSA. Journal
of Nuclear Medicine 6: 711-723, 1965. (PubMed)
Collier, R. E.; G. A. Balla; J. W. Finney; A. D. D'Errico; J. W. Tomme; J. E. Miller & J. T.
Mallams, Differential Localization of Isotopes in Tumors Through the Use of Intra-arterial
Hydrogen Peroxide: Clinical Evaluation. American Journal of Roentgenology, Radium
Therapy and Nuclear Medicine 94(4): 789-797, 1965. (PubMed)
Finney, J. W.; R. E. Collier; G. A. Balla; J. W. Tomme; J. Wakley; G. J. Race; H. C. Urschel; A. D.
D'Errico & J. T. Mallams, Preferential Localization of Radioisotopes in Malignant Tissue by
Regional Oxygenation. Nature 202: 1172-1173, 1964. (PubMed)
Finney, James W.; George A. Balla; Richard E. Collier; Jack Wakley; Harold C. Urschel & John T.
Mallams, Differential Localization of Isotopes in Tumors Through the Use of Intra-arterial
Hydrogen Peroxide: Basic Science. American Journal of Roentgenology, Radium Therapy
and Nuclear Medicine 94(4): 783-788, 1965. (PubMed)
Gastroenterology/digestive disease
Aubourg, Paul, 119 Cas de Colibacillose Traités par L´ozone. Presse Medicale 103: 1897-1900,
1938.
Behar, R.; C. E. Carcía; J. Sardiñas; S. Menéndez; M. Gómez; C. Lemagne & C. Alvarez,
Tratamiento de la ulcera gastroduodenal con ozono. Revista CENIC Ciencias Biológicas
20(1-3): 59-61, 1989.Bulynin, V. I. & A. A. Glukhov, [Treatment of peritonitis using ozone and hydropressive
technology.] Khirurgiia 1999 (7), 9-11. (Written in Russian). (abstract)
Eberhardt, H. G., Mobilisierung des darmassoziierten Immunsystems durch Ozon.
Erfahrungsheilkunde 49: 747-752, 2000.
Glukhov, A. A. & N. V. Shapovalova, [Complex program of detoxication measures in terminal
peritonitis using ozone and hydropressive technologies]. Anesteziologiia i reanimatologiia
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Glukhov, A. A.; A. I. Zhdanov & A. A. Andreev, [The method of parietal-cavitary sanitation of
intestines in complex treatment of acute diffuse peritonitis]. Vestnik khirurgii imeni I. I.
Grekova 163(2): 41-45, 2004. [Written in Russian] (abstract)
Ianovoi, V. V.; E. V. Priadko; & A. A. Totskii, [Complications of an inflammatory nature in the
presacral wound after an operation for abdominal-anal resection with downward
repositioning of the colon]. Vestnik Khirurgii imeni I. I. Grekova 147: 102-104, 1991.
[Written in Russian] (abstract)
Izquierdo, María Elena; Martín Martínez; Lázaro Roque & Marisol García, Aplicación del aceite
ionizado en pacientes de 1 A 14 años con Giardiasis. Boletín de Medicina General Integral
Vol. 4. no. 1, 2000.
Méndez, Alberto Ruiz; Roberto León Fernández; Silvia Menéndez & Juan Villalonga, Cimetidina
vs. agua ozonificada en el tratamiento de la ulcera gastroduodenal. Estudio preliminar.
Revista Cubana de Medicina 27: 7-13, 1988.
Méndez, Nazarina Ivonne; José L. Calunga & Silvia Menéndez, Ozonoterapia en el síndrome de
malabsorción intestinal secundario a paratismo por Giardia lamblia: estudio preliminar.
Revista Cubana de Investigaciones Biomédicas 22: 145-149, 2003. (full text, pdf)
Riva Sanseverino, E; P. Castellacci & P. Sotgiu, Effetti positivi della ossigeno-ozonoterapia in
rettocolite ulcerosa cronica. Descrizione di un caso. Rivista Italiana di OssigenoOzonoterapia 3: 61-64, 2004. (abstract)
Sardiña, J. O.; R. Behar; C. E. Carcía; M. Gómez; S. Menéndez; M. Alvarez & C. Lemagne,
Tratamiento de la giardiasis recidivante con ozono. Revista CENIC Ciencias Biológicas
20(1-3): 61-64, 1989.
Serova, A. N.; G. A. Boyarinov; S. V. Muratov & V. L. Panteleyev, The Influence of Ozonized
Solutions on the Oxyntic Function of a Stomach of Patients with Peptic Ulcer of a Bulb of a
Duodenal Intestine. In: Proceedings of the 15th Ozone World Congress, 11th - 15th
September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd,
Ealing, London, UK, 2001.
Vasil'ev, I. T.; I. N. Markov; R. B. Mumladze;A. A. Belopol'skii & T. A. Vasina, [The antibacterial
and immunocorrective action of ozone therapy in peritonitis]. Vestnik khirurgii imeni I. I.
Grekova 154(3): 56-60, 1995. [Written in Russian]. (abstract)
Dentistry
Abu-Naba’a, Layla & Edward Lynch, Clinical Management of Pit and Fissure Caries Using Ozone
and Some research Results. In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp.
125-142, Quintessence Publishing, UK, 2004.
Baysan, Aylin & Edward Lynch, Effect of ozone on the oral microbiota and clinical severity of
primary root caries. American Journal of Dentistry 17: 56-60, 2004. (abstract)
Baysan, Aylin & Edward Lynch, Clinical Management of Root Caries Using Ozone, In: Ozone:
The Revolution in Dentistry, Edward Lynch ed., pp. 173-180, Quintessence Publishing, UK,
2004.
Baysan, Aylin & Edward Lynch, Use of Sealants Over Ozone Remineralised Root Caries, In:
Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 181-186, Quintessence
Publishing, UK, 2004.
Holmes, J., Clinical reversal of root caries using ozone, double-blind, randomised, controlled 18-
month trial. Gerodontology 20: 106-114, 2003. (abstract / full text PDF)Huth, Karin Christine & Reinhard Hickel, The role of Ozone in “Minimal Intervention Dentistry”.
In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 117-124, Quintessence
Publishing, UK, 2004.
Huth, Karin Christine; Ekaterini Paschos; Korbinian Brand & Reinhard Hickel, Effect of ozone on
non-cavitated fissure carious lesions in permanent molars. A controlled prospective clinical
study. American Journal of Dentistry 18(4): 223-228, 2005. (abstract)
Megighian, Giovanni Dicran, The Clinical Experience in a Private General Dental Practice in Italy,
In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 243-256, Quintessence
Publishing, UK, 2004.
Steier, Liviu & Gabriela Steier, Ozone: an Adjuvant For Long-Term Success in Restorative
Dentistry, In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 257-273,
Quintessence Publishing, UK, 2004.
Steier, Liviu & Gabriela Steier, Ozone Application in Root Canal Disinfection, In: Ozone: The
Revolution in Dentistry, Edward Lynch ed., pp. 2575-285, Quintessence Publishing, UK,
2004.
Stockleben, Carsten, HealOzone – a Revolution in Dentistry, In: Ozone: The Revolution in
Dentistry, Edward Lynch ed., pp. 215-241, Quintessence Publishing, UK, 2004.
Abstracts
Abu-Naba’a, L.; H. Al Shorman & E. Lynch, In vivo Treatment of Occlusal Caries with Ozone:
Immediate Effect and Correlation of Diagnostic Methods [abstract]. Caries Research 36:
189, 2002.
Abu-Naba’a, L.; H. Al Shorman & E. Lynch, Ozone Efficacy in the Treatment of Pit and Fissure
Caries [abstract]. Journal of Dental Research 82(Spec Iss C): C-535, 2003.
Abu-Naba’a, L.; H. Al Shorman & E. Lynch, 6-Month Clinical Indices Changes after Ozone
Treatment of Pit and Fissure Caries (PFC) [abstract]. Journal of Dental Research 82(Spec Iss
B): B-135, 2003.
Abu-Naba'a L.; H. Al Shorman & E. Lynch, Ozone Treatment of Primary Occlusal Pit and Fissure
Caries: 12-Month Clinical Severity Changes [Abstract]. Caries Research 37: 272, 2003.
Abu-Naba'a L.; H. Al Shorman & E. Lynch, Ozone Treatment of Primary Occlusal Pit and Fissure
Caries: 12-Month Electrical Impedance Results and Clinical Implications [abstract]. Caries
Research 37: 272-273, 2003.
Abu-Salem, O. T.; M. M. Marashdeh & E. J. Lynch, Ozone Efficacy in Treatment of Occlusal
Caries in Primary Teeth [abstract]. Journal of Dental Research 82(Spec Iss B): B-136, 2003.
Abu-Salem, O. T.; M. M. Marashdeh & E. J. Lynch, Immediate Effect of Ozone on Occlusal Caries
of Primary Teeth [abstract]. Journal of Dental Research 82(Spec Iss C): C-535, 2003.
Al Shorman, H.; L. Abu-Naba’a & E. Lynch, Patients’ Attitude to Treatment of Pit and Fissure
Caries with Ozone [abstract]. Caries Research 36: 187, 2002.
Baysan, A. & E. Lynch, Safety of an Ozone Delivery System during Caries Treatment in-vivo
[abstract]. Journal of Dental Research 80(4): 1159, 2001.
Baysan, A. & E. Lynch, Management of Primary Root Carious Lesions Using Ozone in vivo
[abstract]. Journal of Dental Research 80(AADR Abstracts): 37, 2001.
Baysan, A., Clinical reversal of root caries using ozone [abstract]. Journal of Dental Research
81(Spec Iss A): A-343, 2002.
Clifford, C., Succesful Use of Airbrasion in Conjuction with Ozone Treatment [abstract]. Journal
of Dental Research 82(Spec Iss B): B-353, 2003.
Cronshaw, M. A., Treatment of Primary Occlusal Pit and Fissure Caries with Ozone: Six-month
Results [abstract]. Journal of Dental Research 82(Spec Iss B): B-354, 2003.
Dähnhardt, J. E.; T. Jaeggi; N. Scheidegger; N. Kellerhoff; P. Francescus & A. Lussi, Treating
Caries in Anxious Children with Ozone: Parent’s Attitudes after the First Session [abstract].
Journal of Dental Research 82(Spec Iss B): B-265, 2003.
Domingo, H.; C. Smith; R. Freeman & E. Lynch, Patients Attitudes to Managing Caries with
Ozone [abstract]. Journal of Dental Research 81(Spec Iss A): A-183, 2002.
Domingo, H.; L. Abu-Naba’a; H. Al Shorman; C. Smith; R. Freeman & E. Lynch, Reducing
Barriers to Care in Patients Managed with Ozone [abstract]. Journal of Dental Research
82(Spec Iss C): C-535, 2003.Holmes, J., Clinical Reversal of Occlusal Pit and Fissure Caries Using Ozone [abstract]. Journal of
Dental Research 82(Spec Iss B): B-354, 2003.
Holmes, J. & E. Lynch, Clinical reversal of occlusal fissure caries using ozone [abstract]. Journal
of Dental Research 82(Spec Iss C): C-535, 2003.
Johnson, N.; J. Johnson; K. Johnson & E. Lynch, Effective Treatment of Occlusal Fissure Caries
Using Ozone [abstract]. Journal of Dental Research 82(Spec Iss B): B-354, 2003.
Johnson, N.; J. Johnson; H. Domingo & E. Lynch, Comparison of Conventional Treatment vs.
Ozone for Occlusal Caries with Ozone Therapy [abstract]. Journal of Dental Research
82(Spec Iss B): B-354, 2003.
Lynch, E.; A. Baysan; C. J. Silwood & M. Grootveld, Therapeutic Oxidizing Activity of a Novel
Antibacterial Ozone-Generating Device on Primary Root Caries [abstract]. Caries Research
32: 300-301, 1998.
Megighian, G. D. & L. Bertolini, In vivo treatment of Occlusal Caries with Ozone: One and Two
Months’ Effect with Light-induced Fluorescence (QLF) as Diagnostic Methods [abstract].
Journal of Dental Research 82(Spec Iss B): B-354, 2003.
Megighian, G. D.; A. Bertolini; A. De Pieri & E. Lynch, In-vivo Treatment of Occlusal Caries with
Ozone [abstract]. Journal of Dental Research 82(Spec Iss C): C-535, 2003.
Morrison, R., Efficacy of ozone to Reverse Occlusal Caries [abstract]. Journal of Dental Research
82(Spec Iss B): B-354, 2003.
Remiszewski, A., P. Sobiech & M. Sobczak, Management of patients with early caries using ozone
therapy – a preliminary study [abstract]. International Journal of Paediatric Dentistry
15(Suppl. 2): 33-38, 2005.
Stinson, P., Clinical Reversal of Occlusal Pit and Fissure Caries after Using Ozone [abstract].
Journal of Dental Research 82(Spec Iss B): B-354, 2003.
Stomatology
Brauner, A., Klinische Untersuchung über den therapeutischen Erfolg von ozonisiertem Wasser bei
Gingivitis und Parodontitis. Zahnärtliche Praxis 42(2): 48-50, 1991.
Carreira, Victoria & Zoraya E. Almagro, Efectividad del Oleozón en el tratamiento de la estomatitis
subprótesis. Revista Cubana de Estomatologia 37: 140-145, 2000. (full text, PDF)
Chahverdiani, B. & A. Thadj-Bakhche, L'Ozontherapie En Traitement Radiculaire. Acta Medica
Iranica XIX: 192-200, 1976. (PubMed)
Cruz, Olga; Silvia Menéndez; Odalys Reyes & Wilfredo Díaz, Aplicación de la ozonoterapia en el
tratamiento de conductos radiculares infectados. Revista Cubana de Estomatologia 31(2): 47-
51, 1994.
Cruz, Olga; Silvia Menéndez; Maria E. Martínez & Teresita Clavera, Aplicación de la ozonoterapia
en el tratamiento de la alveolitis. Revista Cubana de Estomalogia 34: 21-24, 1997. (full text)
Filippi, A., Lokalbehandlung von Ostitis Circumscripta mit ozonisiertem Olivenöl. Quintessenz 44:
1531-1537, 1993.
Filippi, A., Bewährung der Wasserdesinfektion zahnärztlicher Behandlungseinheiten durch Ozon.
Deutsche Zanhärztliche Zeitschrift 50: 708-710, 1995.
Filippi, Andreas, The Influence of Ozonized Water on the Epithelial Wound Healing Process in the
Oral Cavity. In: Proceedings of the 15th Ozone World Congress, 11th - 15th September
2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing,
London, UK, 2001. (full text PDF)
Fisch, E.-A., L´ozone en médecine dentaire comme nouveau moyen de thérapeutique. Revue
Odontologique LVII: 619-638, 1936.
Fisch, E. A., Ueber Anwendung von ozon in der Stomatologie, als wirksames Mittel einer
neuzeitlichen Therapie. Deutsche Zahnärztliche Wochenschrift 40: 943-946, 1936.
Fisch, E. A., Ueber Anwendung von ozon in der Stomatologie, als wirksames Mittel einer
neuzeitlichen Therapie. Deutsche Zahnärztliche Wochenschrift 41: 971-974, 1936.García, Eneida; Alina Roche; Antonio Osvaldo Blanco & Luis Orlando Rodríguez, La ozonoterapia
en el tratamiento de la estomatitis subprótesis. Revista Cubana de Estomatologia Vol. 40 No.
2, 2003. (htm full text)
González, Liana; Francisco Rosell; Adalberto Dorrego & Mercedes Haces, Efecto de la
ozonoterapia en la gingivoestomatitis herpética aguda. Boletin de Medicina General Integral
Vol. 4. No. 2, 2000. (full text)
Goldstein, Louis S., The treatment of acute herpetic gingivostomatitis with ozonide of olive oil.
New York State Journal of Medicine 50: 1252, 1950. (PubMed)
Mena, Libia; Silvia Menéndez & Elia Omechevarria, Efectos del ozono en el tratamiento de la
gingivoestomatitis herpética aguda. Revista Cubana de Estomatologia 31(1): 14-17, 1994.
Overdiek, H. Fr. & L. Honrath, Klinische Beobachtungen und Testergebnisse bei der Ozonisierung
gangränöser Wurzelkanäle. Zanhnärztliche Welt 6(16): 373-376, 1951.
Turrent, José; Giselda Legrá; Silvia Menéndez & Maria del C. Luis Alvarez, Ozonoterapia en la
enfermedad de Sutton (periadenitis mucosa necrótica recurrente). Revista CENIC Ciencias
Biológicas 29: 157-160, 1998.
Viral diseases
Balkanyi, Alexander, Herpes Zoster – a Treatment Concept with Ozone. In: Proceedings of the
15th Ozone World Congress, 11th - 15th September 2001, Medical Therapy Conference
(IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK. (full text PDF)
Bocci, Velio; Giulietta Venturi; Marinunzia Catucci; Pier Egisto Valensin & Maurizio Zazzi, Lack
of efficacy of ozone therapy in HIV infection. Clinical Microbiology & Infection 4: 667-669,
1998. (Comment by Miika Sallinen)
Carpendale, Michael T. & John Griffiss, Is there a role for medical ozone in the treatment of HIV
and associated infections? In: Ozone in Medicine: Proceedings of the 11
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Congress (Stamford, CT., International Ozone Association, Pan American Committee) M-1-
32-M-1-45, 1993. (abstract)
Carpendale, Michael T.; Joel K. Freeberg & John McLeod Griffiss, Does Ozone Alleviate AIDS
Diarrhea? Journal of Clinical Gastroenterology 17: 142-145, 1993. (abstract)
Delgado, J.; R. Wong; S. Menéndez & M. Gómez, Tratamiento con ozono del herpes zoster.
Revista CENIC Ciencias Biológicas 20(1-3): 160-161, 1989.
Garber, Gary E.; D. William Cameron; Nanci Hawley-Foss; Donald Greenway & Michael E.
Shannon, The use of ozone-treated blood in the therapy of HIV infection and immune
disease: a pilot study of safety and efficiacy. AIDS 5: 981-984, 1991. (abstract)
Hooker, M. H. & B. G. Gazzard, Ozone-treated blood in the treatment of HIV infection. AIDS 6:
131, 1991.
Kief, H., Studie über Chronische Hepatitis und Ozontherapie. Erfahrungsheilkunde 32(5): 276-283,
1983.
Kief, H., Die Behandlung von Viruserkrankungen mit ozon. Erfahrungsheilkunde 37(7): 438-446,
1988. (abstract)
Kief, Horst, Derzeitiger Stand der Behandlung von HIV-positiven Patienten mit Ozon - eine
Übersicht. Naturheilpraxis 9/1988: 1043-1049, 1988.
Kief, Horst, Ozone and The Auto-homologous Immune Therapy in AIDS Patients. Monography:
Ludwigshafen, Germany 1993.
Mawsouf, Mohamed Nabil; Taha Tarek Tanbouli & Wagdy Ibrahim El-Tayar, Ozone Therapy in
Patients with Viral Hepatitis “C”: A Clinical Study. In (CD-ROM): Ozone Seminar
Congress, European Cooperation of the Medical Ozone Societies, May 23
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Munich 2003. (PDF)
Méndez, Nazarina Ivonne; Silvia Menéndez & José Rivero, Ozonoterapia en SIDA. Revista
Cubana de Investigaciones Biomédicas 24(1): 69-71, 2005 (full text)
Oliver, T. H. & D. V. Murphy, Influenzal Pneumonia: The Intravenous Injection of Hydrogen
Peroxide. Lancet, February 21, 1920, 432-433.Shallenberger, F., Selective compartmental dominance: an explanation for a noninfectious,
multifactorial etiology for acquired immune deficiency syndrome (AIDS), and rationale for
ozone therapy and other immune modulating therapies. Medical Hypotheses 50: 67-80, 1998.
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Abstracts
Guerra Segura, Osmel Gaspar & Barbara Elias-Calles Fernandez, Ozonetherapy and Quality of Life
in HIV Positive Patients [abstract]. Clinical Immunology 115(suppl. 1): S164, 2005.
Sammartino, A.; P. Esposito; L. Mascolo; M. Luongo; V. La Mura & C. Luongo, New diagnostic
therapeutic approach in chronic hepathopathic patients post-HBV and HCV necrotics
[abstract]. European Journal of Clinical Investigation 33(Suppl. 1): 45-46, 2003.
Otorhinolaryngology
Basabe, Ernesto; Vivian Borroto; Luis Bell; Silvia Menéndez; Carlos López; Maria de los Angeles
Alarcon, Respuesta mediante efecto Doppler del tronco vértebro-basilar de pacientes con
síndrome cócleovestibular incompleto tratados con ozonoterapia y acupunctura. Revista
CENIC Ciencias Biológicas 29: 185-188, 1998. (abstract)
Chernekhovskaia, N. E.; I. V. Iarema; V. K. Shishlo; V. G. Andreev & D. V. Khodos, [Intratracheal
lymphotropic ozone therapy in erosive-ulcerous tracheitis]. Vestnik khirurgii imeni I. I.
Grekova (2001), 160(1), 86-8. (Written in Russian). (abstract)
Corteloy, P. R., 80 Years Ago: Use of Peroxide of Hydrogen in Diseases of the Throat and Nose.
Journal of the Medical Association of Georgia 57: 449-450, 1968.
Nachín, Victoriano; José Turrent; Silvia Menéndez & Adel Hernández, Ozonoterapia y laserpuntura
en el tratamiento de la sordera súbita. Revista Cubana de Cirugía 43(3-4), 2004. (full text
PDF)
Ovchinnikov I. M. & E. V. Sin´kov, [Use of gaseous ozone and ozonized solutions in the treatment
of chronic suppurative otitis media.] Vestnik Otorinolaringologii (1998), (6), 11-12. (Written
in Russian). (abstract)
Pawlak-Osinska, Katarzyna; Henryk Kazmierczak; Wojciech Kazmierczak & Magdalena Szpoper,
Ozone Therapy and Pressure-Pulse Therapy in Ménière's Disease. International Tinnitus
Journal 10: 54-57, 2004. (abstract)
Reinecker, R., Ozongastherapie bei Erkrankungen des Ohres. Zeitschrift für Laryngologie,
Rhinologie, Otologie und ihre Grenzgebiete 36: 108-113, 1957.
Shakov, V. I. & A. N. Edeleva, [Reasons for the application of medical ozone in the treatment of
chronic purulent mesotympanitis.] Vestnik Otorinolaringologii (1999), (2), 48-49. [Written in
Russian]. (abstract)
Wehner, H., Kombination von Ozon- und Sauerstoff-Mehrschritt-Therapie bei Tinnitus - ein
Praxisbericht. Erfahrungsheilkunde 48(12): 760-761, 1999.
Liver diseases (Hepatitis: see viral diseases)
Nedogoda V. V.; O. V. Razvaliaeva & A, G Kulikov, [Effect of ozonotherapy on lipid peroxidation
in patients with chronic diffuse liver diseases]. Voprosy kurortologii, fizioterapii, i lechebnoi
fizicheskoi kultury (2001 Jul-Aug), (4), 19-21. [Written in Russian]. (PubMed)
Parkhisenko, Iu. A. & S. V. Bil'chenko, [The ozone therapy in patients with mechanical jaundice of
tumorous genesis]. Vestnik khirurgii imeni I. I. Grekova (2003), 162(5), 85-7. [Written in
Russian]. (abstract)
Sinenchenko, G. I.; M. Iu. Kabanov & S. V. Tikhonchuk, [Perspectives of using ozonized solutions
in complex treatment of patients with mechanical jaundice], Vestnik khirurgii imeni I. I.
Grekova 163(3): 91-94, 2004. [Written in Russian] (PubMed)
Wong, R.; R. Rivero; S. Menéndez & M. Gómez, Ozonoterapia en la esteatosis hepatica. Revista
CENIC Ciencias Biológicas 20(1-3): 157-159, 1989.Hematological diseases
Espinosa, Edgardo E. & Sigrid Marichal, Ozonoterapia en el tratamiento de las crisis vasooclusivas, en pacientes con anemia drepanocítica. 16 de Abril, Vol 39 No. 2, 2000. (full text)
Menéndez, Silvia; Edgardo Espinosa; James A. Caplan & Wilfredo Díoz, Application of medical
ozone therapy in patients with sicle cell anemia. Preliminary report. In: Ozone in medicine:
Proceedings of the 11
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Association, Pan American Committee) M-2-12-M-2-18, 1993. (abstract)
Gynecology
Andikyan, V. M.; I. N. Voloshchuk; P. A. Kovganko & J. M. Clemente, [Morphofunctional
changes in the placenta after ozone therapy]. Biulleten' eksperimental'noj biologii i
meditsiny 130(7): 117-120, 2000. [Written in Russian]
Cardia, Mario; Alberto Vieira da Cruz & Luis Domingues, Sobre o tratamento e reinfestações nas
vaginites por tricomonas. Acta gynaecologica et obstetrica Hispano-Lusitana 4(4): 286-292,
1955. (PubMed)
Cardia, Mario; Traitement des rtichomoniases vaginales par l'ozone. Comptes rendus de la Societe
francaise de gynecologie 26(1): 28-32, 1956. (PubMed)
Chandra-D´Mello, Rajani & Ronald D´Mello, Ozone Therapy in Female Infertility. In: Proceedings
of the 15th Ozone World Congress, 11th - 15th September 2001, Medical Therapy
Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001. (full text
PDF)
Chernukha, Ye. A.; V. A. Burlev; S. K. Kochieva; I. I. Baranov; S. V. Pavlovich; N. A. Korotkova
& M. L. Kochieva, [Use of medical ozone after cesarean section]. Akusherstvo i
Ginekologiya №4, 25-27, 2002. [Written in Russian] (abstract)
Gretchkanev, Guennadi O.; Claudia N. Kontorchikova; Tatyana S. Kachalina & El Hassoun
Husein, The Experimental Grounds for Safe and Effective Dosage of Medical Ozone used in
the Treatment of Abortion. In: Proceedings of the 15th Ozone World Congress, 11th - 15th
September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd,
Ealing, London, UK, 2001. (full text PDF)
Gretchkanev, Guennadi O.; Tatyana S. Kachalina; Olga V. Kachalina & El-Hassoun Husein, The
New Method of Treatment of Inflammatory Diseases of Lower Female Genital Organs. In:
Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical
Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
(full text PDF)
Gretchkanev, Guennadi O.; Tatyana S. Kachalina; Olga V. Kachalina; N. N. Saifieva & El-Hassoun
Husein, The Treatment of Endometritis in Combination with Ozonetherapy. In: Proceedings
of the 15th Ozone World Congress, 11th - 15th September 2001, Medical Therapy
Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001. (full text
PDF)
Kachalina, Tatiana S.; Artem V. Soshnikov & Gennady O. Gretchkanev, Ozonetherapy in Complex
Treatment of Obese Pregnant Women. In: Proceedings of the 15th Ozone World Congress,
11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint
Macmedia Ltd, Ealing, London, UK, 2001. (full text PDF)
Kachalina, Tatiana S.; Nadezhda Yu. Katkova & Gennady O. Gretchkanev, Application of Ozone
in Prevention and Treatment of Intrauterine Fetus Infection. In: Proceedings of the 15th
Ozone World Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA
2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001. (full text PDF)
Kachalina, T. S.; A. V. Soshnikov & G. O. Grechkanev, [Effect of medical ozone on the course of
pregnancy and labor in women with exogenous constitutional obesity]. Akusherstvo i
Ginekologiya №3, 21-25, 2002. [Written in Russian] (abstract)
AbstractsPobedynsky, N. M.; V. M. Zuev; D. G. Krasnicov; T. A. Djibladze & L. S. Alexandrov. The
effectiveness of ozone in the treatment of chronic fetal hipoxia P43.133 [abstract]. Acta
Obstetricia et Gynecologica Scandinavica - Supplement. 76 Supplement 167(1):79, 1997.
Sarapulova, N.; N. Guryanova & T. Kolesova, Comparative evaluation of effectiveness of
urogenital clamidiosis treatment with antibiotics and ozonotherapy: R2174 [abstract].
Clinical Microbiology & Infection Supplement. 11 Supplement 2:721, 2005.
Zuev, V. M.; N. M. Pobedynsky; D. G Krasnicov; T. A. Djibladze & Z. S. Dedenko, The effeciency
of ozonotherapy in the treatment of patients with viral infection and abnormal pregnancy
P65.18 [abstract]. Acta Obstetricia et Gynecologica Scandinavica - Supplement. 76
Supplement 167(3):77, 1997.
Blood/Tissue oxygenation and performance
Abeatici, S.; V. Laugeri; Th. De Nunno & M. Querci, Sulla somministrazione endovenosa di
solozioni di perossido d'idrogeno: prime applicazione cliniche. Minerva Medica 50(18): 654-
656, 1959. (PubMed)
Balla, G. A.; J. W. Finney & J. T. Mallams, A Method for Selective Tissue Oxygenation Utilizing
Regional Intra-Arterial Infusion Technics. American Surgeon 29: 496-498, 1963. (PubMed)
Clavo, Bernardino; Juan L. Perez; Laura Lopez; Gerardo Suarez; Marta Lloret; Victor Rodriguez;
David Macias; Maite Santana; Jesus Morera; Dolores Fiuza; Francisco Robaina & Martina
Gunderoth, Effect of ozone therapy on muscle oxygenation. Journal of Alternative and
Complementary Medicine 9: 251-256, 2003. (abstract)
Germon, Patricia A.; Donald S. Faust; Arthur Rosenthal & Luther W. Brady, Regional Arterial and
Tissue Oxygen Tensions in Man During Regional Infusion with Hydrogen Peroxide
Solutions. Radiology 88: 589-591, 1967. (PubMed)
Germon, Patricia A.; Donald S. Faust & Luther W. Brady, Comparison of Arterial and Tissue
Oxygen Measurements in Humans Receiving Regional Hydrogen Peroxide Infusions and
Oxygen Inhalation. Radiology 91: 669-672, 1968. (PubMed)
Gerasimenko, N. I.; A. A. Priimak; S. A. Segedi & A. L. Musarov, [Endogenous oxygenation with
hydrogen peroxide]. Vestnik Khirurgii 121(7): 127-32, 1978 (Written in Russian) (PubMed)
Mallams, J. T.; J. W. Finney & G. A. Balla, The Use of Hydrogen Peroxide As A Source of
Oxygen in A Regional Intra-Arterial Infusion System. Southern Medical Journal 55: 230-
232, 1962. (PubMed)
Rogers, Lloyd S. & Bedros Manguikian, Intra-arterial Hydrogen Peroxide and Tissue Oxygenation.
Journal of Surgical Research 5: 463-470, 1965. (PubMed)
Wong, R.; A. Soler; D. Torriantes; A. Noriega; S. Menéndez & M. Gómez, Ozonoterapia y estudio
gasometrico. Revista CENIC Ciencias Biológicas 20(1-3): 136-144, 1989.
Hormonal balance
Basabe, Ernesto; Luis Bell; Silvia Menéndez; Rafael Bell & José A. Núñez, Perfil hormonal de
niños con discapacidad auditiva tratados con ozonoterapia. Revista CENIC Ciencias
Biológicas 29: 153-156, 1998. (abstract)
Immune stimulation
Corcho, Ivonne; Frank Hernández; Natacha Reyes; Ana L. Carballo; Orlando Peña; Tania Reyes &
Lubia Yanes, Cambios del sistema inmune en procesos inflamatorios durante la aplicación de
la ozonoterapia. Revista CENIC Ciencias Biológicas 29: 203-205, 1998. (abstract)Kucharenka, E. I.; T. V. Vorontsova; E. V. Ostapenko, E. N. Shavrova, E. A. Kuchinskaya; S. V.
Michailiuk & A. I. Filimonov, [Influence of ozonotherapy on immune state of high
qualification sportsmen]. Immunopathology, Allergology and Infectology 3: 38-45, 2002.
(PDF full text in Russian)
Ramos, J.; M. Torres; E. Aguilar; A. Ostolaza; M. Gómez; S. Menéndez; R. García; L. A. Cuza; M.
Vargas; M. Verdecia & G. Lezcano, Estudio inmunologico de 25 pacientes grandes
quemados tratados con ozono. Revista CENIC Ciencias Biológicas 20(1-3): 116-120, 1989.
Psychiatric disorders
Basabe, Ernesto; María Miranda; Gladys Rodríguez; Silvia Menéndez; Natalia V. Sheshukova;
Adela Soto; María del Carmen Carballo; Xiomara García & María de los Angeles Alarcon,
Resultados psicopedagógicos en niños con discapacidad auditiva, despues de 3 y 5 años del
tratamiento de ozonoterapia. Revista CENIC Ciencias Biológicas 29: 169-173, 1998.
(abstract)
Dementia and Parkinson's disease
Llibre, Juan de J.; Juan A. Samper & Zoila Pérez, Tratamiento de la demencia senil tipo Alzheimer
con campo magnético y ozono. Revista Cubana de Medicina Militar 24: 69-77, 1995. (full
text)
Rodríguez, Maria M; Silvia Menéndez; Evis Devesa; Josue García; Mayra Carrasco; Ana Carballo
& Wilfredo Díaz, Ozone therapy for senile dementia. In: Ozone in Medicine: Proceedings of
the 11
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American Committee) M-2-12-M-3-18, 1993.
Rodríguez, María M.; Josué R. García; Silvia Menéndez; Evis Devesa & Regla González,
Ozonoterapia en el tratamiento de la demencia senil. Revista CENIC Ciencias Biológicas 29:
141-144, 1998. (abstract)
Rodríguez, María M.; Silvia Menéndez; Josué R. García, Evis Devesa & A. Cámbara, Ozonoterapia
en el tratamiento de los síndromes Parkinsonianos del anciano. Revista CENIC Ciencias
Biológicas 29: 149-152, 1998. (abstract)
Pulmonary diseases
Hernández, Frank; Idania Alvarez; Ivonne Corcho & Maritza González, Changes in Glutathione
Antioxidant Pathway Components, HLA-DR and IgE in Blood from Asthma Patients Treated
with Ozone Therapy. In: Proceedings of the 15th Ozone World Congress, 11th - 15th
September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd,
Ealing, London, UK, 2001.
Hernández Rosales, Frank A.; José L. Calunga Fernández; José Turrent Figueras; Silvia Menéndez
Cepero & Adonis Montenegro Perdomo, Ozone Therapy Effects on Biomarkers and Lung
Function in Asthma. Archives of Medical Research 36: 549-554, 2005. (abstract)
Kief, H., Die Behandlung des Asthma bronchiale mit der autohomologen Immuntherapie (AHIT).
Erfahrungsheilkunde 9/1990: 534-542, 1990. (summary)
Diabetes
Maslennikov, O. V.; V. F. Bolgov; O. A. Bolgova; I. A. Gribkova; E. E. Pavlovskaja & R. Skalskis,
Cukrino diabeto gydymas ozonu. Medicinos Teorija ir Praktika 40: 343-345, 2004. (Written
in Lithuanian)Fibromyalgia
Abstract
Cosentino, R., Efficacy of oxygen–ozone therapy in fibromyalgia [abstract]. European Journal of
Clinical Investigation 33 (1. suppl.) 45, 2003.
Burns
Aguilar, E.; M. de los A. Torres; J. M. Ramos; A. Ostolaza; M. Gómez; S. Menéndez; R. García; L.
A. Guza; M. Vargas; M. Verdecia; & G. Lezcano, Recuperacion de la inmunosupresion
humoral en en quemado critico por ozonoterapia. Presentación de un caso. Revista CENIC
Ciencias Biológicas 20(1-3): 106-110, 1989.
García, R.; E.Ruiz; J. Ramos; M. Verdecia; L. A. Cuza; M. Vargas; G. Lezcano; M. A. Torres; S.
Menéndez; M. Gómez & E. Enriquez, Estudio electrocardiografico en grandes quemados
tratados por autohemoterapia con ozono. Valoracion de 20 pacientes y 37 sesiones. Revista
CENIC Ciencias Biológicas 20(1-3): 104-106, 1989.
García, R.; S. Menéndez; M. Gómez; L. A. Cuza; J. Ramos; A. Sanfiel; W. Díaz; M. Verdecia; M.
Vargas; G. Lezcano; M. A. Torres & E. Enríguez, El ozono como coadyuvante en el
tratamiento de un paciente quemado critico. Revista CENIC Ciencias Biológicas 20(1-3):
111-115, 1989.
Luccioni, F.; M. Mosinger; M. Carcassonne & J.-P. Jouglard, Le traitement des brulures par la
méthode des sacs occlusifs et des chambres individuelles sous oxygéne ou ozone. Marseille
Chirurgical 13: 250-254, 1961. (PubMed)
Luccioni, F.; M. Mosinger & L. Aboucaya, L´oxygénothérapie en "vase clos" dans le traitement des
brûlures. Presse Medicale 73(51): 2945-2947, 1965. (PubMed)
Peretyagin, Sergey P.; Olga V. Kostina; Andrey A. Struchkov; Sergey A. Vilkov; Artem L.
Borisevitch; Dmitriy G. Dmitriev & Vagap A. Shichragimov, Methodology of using Ozone
in the Comlex Treatment of Burn Disease at Early Stage. In: Proceedings of the 15th Ozone
World Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.),
Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
Rasterayeva, M.; S. Struchkov; A. Belova; S. Peretaygin & S. Khroulev; Ozonetherapy in complex
treatment of neuropathy in burn patients. In: Proceedings of the 15th Ozone World Congress,
11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint
Macmedia Ltd, Ealing, London, UK, 2001.
Sepsis
Rabell, S.; A. Menéndez; P. L. Alonso; F. Gutiérrez; J. Valdés; A. Díaz; A. Ruibal; M. Gómez & S.
Menéndez, La terapia con ozono y la prevencion de la sepsis en el enfermo critico. Revista
CENIC Ciencias Biológicas 20(1-3): 124-127, 1989.
Turrent, José & Silvia Menéndez, Ozone Therapy: Experiences in Critically ill Patients. In:
Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical
Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
(full text PDF)
Case reports on the various pathologiesBiedunkiewicz, Bogdan; Leszek Tylicki; Monika Lichodziejewska-Niemierko; Tomasz Liberek &
Boleslaw Rutkowski, Ozonetherapy in a dialyzed patient with calcific uremic arteriolopathy.
Kidney International 64: 367-368, 2003. (PubMed)
Clavo, Bernardino; Dominiga Gutiérrez; Dionisio Martín; Gerardo Suárez; María A. Hernández &
Francisco Robaina, Intravesical ozone Therapy for Progressive Radiation-Induced
Hematuria. Journal of Alternative and Complementary Medicine 11(3): 539-541, 2005.
(abstract / full text PDF)
Di Paolo, N.; V. Bocci; F. Cappelletti; G. Ptrini & E. Gaggiotti, Necrotizing fasciitis succesfully
treated with extracorporeal blood oxygenation and ozonization (EBOO). International
Journal of Artificial Organs 25: 1194-1198, 2002. (abstract)
Other clinical studies
Calvo, H.; S. Menéndez; M. Gómez; A. Lacaza & J. Molerio, Experiencias preliminares en la
utilizacion del ozono en pacientes de terapia intensiva del hospital "Carlos J. Finlay". Revista
CENIC Ciencias Biológicas 20(1-3): 128-135, 1989.
Franzini, M.; A. Bignamini; P. Micheletti; L. Valdenassi; G. Agostini; P. Richelmi & F. Berte,
Subcutaneous oxygen-ozone therapy in indurative hypodermatitis and in localised
lipodystrophies: a clinical study of efficacy and tolerability. Acta Toxicologica et
Therapeutica 14(4): 273-288, 1993.
Glady, Gilbert, Diverse pathology treated in medical ozone clinic. In: Ozone in Medicine:
Proceedings of the 11
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Association, Pan American Committee) M-3-1-M-3-4, 1993.
Gorbunov, Sergei N,; Leonid I. Shesterikov & Yury P. Birjukov, The use of ozone in the treatment
of children suffered due to different catastrophes. In: Ozone in Medicine: Proceedings of the
11
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Committee) M-3-31-M-3-33, 1993.
Guerra, Xiomara; Yanet Limonta; Iraida Contrera; Rácife Freyre & Caridad Martínez, Labor de la
enfermera en la aplicación de la ozonoterapia en retinosis pigmentaria. Enero-Mayo, 1998.
Revista Cubana de Enfermeria 15: 99-102, 1998. (full text PDF)
Guerra, Xiomara; Yanet Limonta; Iraida Contrera; Rácife Freyre & Aguera M. Ramírez, Resultados
de los costos en ozonoterapia. Revista Cubana de Enfermeria 15: 104-108, 1999. (full text
PDF)
Hernández, F. S. Menéndez; M. Gómez & L. Eng, Efecto de la ozonoterapia intravascular sobre el
sistema de la glutation peroxidasa. Revista CENIC Ciencias Biológicas 20(1-3): 37-40, 1989.
Herrwerth, E. & L. Brenner, Erfahrungen mit subkutanen Sauerstoff-Ozon-Insufflationen. Ärztliche
Praxis 26: (nr. XV) 213-214, 1963.
Kotov, S. A., [Ozone therapy of migraine]. Zhurnal Nevrologii i Psikhiatrii Imeni S. S: Korsakova
100: 35-37, 2000 (Written in Russian) (abstract)
Love, I. N., JAMA 100 Years Ago: Peroxide of Hydrogen as a Remedial Agent. JAMA: The
Journal of the American Medical Association 259: 1279, 1988.
Maslennikov, Oleg V.; Claudia N. Kontorshchikova; Sergey V. Androsov; Irina A. Gribkova;
Elena E. Pavlovskaya & Elena A. Piatina, Ozonetherapy in the Treatment of Internal
Diseases. In: Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001,
Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London,
UK, 2001.
Recio, Eulalia; Maritza Arias; Magalys Rodriguez & Maria de los Angeles, Aspectos de la
ozonoterapia en pacientes con neuropatía periférica epidémica. Revista Cubana de
Enfermeria 15: 114-118, 1999. (full text, pdf)
Rodríguez; B. R.; S. Menéndez; X. Quesada; C. Vecino & F. Herrera, Utilizacion de la
ozonoterapia en el tratamiento de las hiperlipidemias. Revista CENIC Ciencias Biológicas
20(1-3): 153-156, 1989.Tassorelli, Christina; Giuseppe Micieli; Elena Viotti; Anna Cavallini & Giuseppe Nappi, The role
of pO2/pCO2 in cluster headache pathogenesis: Perspectives of the oxygen/ozone therapy.
Cephalalgia 11(Suppl. 11): 272-273, 1991.
Thompson, Symes E., On the influence of ozonized cod-liver oil on the pulse. Lancet [March 9],
239, 1861. (full text PDF)
Tishko, T. V.; V. P. Titar; T. M. Barchotkina & D. N. Tishko, Application of the holographic
interference microscope for investigation of ozone therapy influence on blood erythrocytes of
patients in vivo. In: Proceedings of CAOL 2003. 1st International Conference on Advanced
Optoelectricts and Lasers, Vol 2 pp. 6-8, Alushta, Crimea, Ukraine, 16-20 September 2003.
(full text PDF)
Torres, M. A. E. Aguilar; J. Ramos; A. Guza; L. A. Ostolabaza; M. Verdecia; M. Vargas;
G.Lezcano; R. García; S. Menéndez; M. Gómez & E. Enriquez, Coagulacion intravascular
diseminada y ozonoterapia. Criterios en la evolucion. Revista CENIC Ciencias Biológicas
20(1-3): 120-124.
Umlauf, Richard, High Frequency Ozone Therapy Based on Acupuncture Systematics.
Acupuncture in Medicine 16(2): 89-94, 1998.
Wolff, Hans, Die Breite Palette der Ozon-Anwendung. Ärztliche Praxis 32 (nr. 92): 3109-3110,
1980.
Veterinary
Alves, G. E. S.; J. M. G. Abreu; J. D. Ribeiro Filho; L. A. L. Muzzi; H. P. Oliveira; R. J. Tannus &
T. Buchanan, Efeitos de ozônio nas lesões de reperfusão do jejuno em eqüinos. Arquivo
Brasileiro de Medicina Veterinaria e Zootecnia 56(4): 433-437, 2004.
Ogata, Atsuya & Hajime Nagahata, Intramammary Application of Ozone Therapy to Acute Clinical
Mastitis in Dairy Cows. Journal of Veterinary Medical Science 62: 681-686, 2000. (abstract)
Scrollavezza, P.; R. Dall´aglio; R. Poldi & G. Pezzoli, The ozonized autohemotransfusion in
halothane-anesthetized horses. In: Ozone in Medicine: Proceedings of the 11
th
Ozone World
Congress (Stamford, CT., International Ozone Association, Pan American Committee) M-3-
53-M-3-55, 1993.
Scrollavezza, Paolo; Francesco Ansaloni; Paolo Polidori; Marco Ablondi & Bruno Pogliacani,
Ozonized autohemotherapy, a new method to treat dairy cow acute interdigital phlegmon.
Comparison with ceftiofur and oxytetracycline. Italian Journal of Animal Science 1: 211-
216, 2002. (full text PDF)
Terasaki, Nobuhiro; Atsuya Ogata; Hiromichi Ohtsuka; Keiji Tamura; Fumio Hoshi; Matesaru
Koiwa & Seichi Kawamura, Changes of immunological response after experimentally
ozonated autohemoadministration in calves. Journal of Veterinary Medical Science 63: 1327-
1330, 2001. (abstract)
Vasogen's immune modulation therapy
Note: this therapy includes only about 10 cc of blood ozonization and exposure to heat and
UV-light, so it's a kind of ozone therapy with very tiny blood amount injected to muscles. In
my opinion this method is not as effective as traditional ozone autohemotherapy or EBOO.
Edvinsson, L. I.; M. L. Edvinsson & G. Angus Deveber, Vasogen's immune modulation therapy
(IMT) improves postischemic foot skin blood flow and transcutaneous pO(2) recovery rates
in patients with advanced peripheral arterial occlusive disease. International Angiology
22(2): 141-147, 2003. (abstract)
Cooke, E. D.;A. G. Pockley; A. T. Tucker; J. D. Kirby & A. E. Bolton, Treatment of severe
Raynaud's syndrome by injection of autologous blood pretreated by heating, ozonation and
exposure to ultraviolet light (H-O-U) therapy. International Angiology 16(4): 250-254, 1997.
(abstract)McGrath, C.; R. Robb; A. J. Lucas; A. H. R. Stewart; C. L. Underwood; J. K. Horridge; P. M.
Lamont, F. C. T. Smith; R. N. Baird & J. J. F. Belch, A Randomised Double Blind, Placebocontrolled Study to Determine the Efficacy of Immune Modulation Therapy in the Treatment
of Patients Suffering from Peripheral Arterial Occlusive Disease with Intermittent
Claudication. European Journal of Vascular and Endovascular Surgery 23(5): 381-387,
2002. (abstract)
Torre-Amione, Guillermo; Francois Sestier; Branislav Radovancevic & James Young, Effects of a
Novel Immune Modulation Therapy in Patients With Advanced Chronic Heart Failure:
Results of a Randomized, Controlled, Phase II Trial. Journal of the American College of
Cardiology 44(6): 1181-1186. (abstract)
Torre-Amione, Guillermo; Francois Sestier; Branislav Radovancevic & James Young, Broad
Modulation of Tissue Responses (Immune Activation) by Celacade May Favorably Influence
Pathologic Processes Associated with Heart Failure Progression. American Journal of
Cardiology 95(suppl): 30C-37C, 2005. (abstract)
Unfortunate events and accidents
Corea, Francesco; Serena Amici; Nicola Murgia & Nicola Tambasco, A Case of Vertebrobasilar
Stroke During Oxygen-ozone Therapy. Journal of Stroke and Cerebrovascular Diseases 13:
259-261, 2004.
Daschner, F. D., Hepatitis C and Human Immunodeficiency Virus Infection Following Ozone
Autohaemotherapy. European Journal of Clinical Microbiology and Infectious Diseases 16:
620, 1997. (PubMed)
Faustini, Annunziata; Maria R. Capobianchi; Mauro Martinelli; Isabella Abbate; Giuseppina
Cappiello & Carlo A. Perucci, A Cluster of Hepatitis C Virus Infections Associated With
Ozone-Enriched Transfusion of Autologous Blood in Rome, Italy. Infection Control and
Hospital Epidemiology 26: 762-767, 2005. (abstract)
Frankum, Bradley & Constance H. Katelaris, Ozone therapy in AIDS - truly innocuous? Medical
Journal of Australia 159: 493, 1993. (PubMed)
Gabriel, Christian; Barbara Blauhut; Rosemarie Greul; Bruno Schneewels & Michael Roggendorf,
Transmission of hepatitis C by ozone enrichtement of autologous blood. Lancet 347: 541,
1996. (PubMed)
Hildebrand, H. E., Lehren aus einem Ozontherapie-Todesfall. Medizinische Welt 38: 1228-1231,
1987.
Hirschtick, Robert E. ; Susan E. Dysda & LoAnn C. Peterson, Death from an Unconventional
Therapy for AIDS. Annals of Internal Medicine 120: 694, 1994.
Lo Giudice, Giuseppe; Franco Valdi; Maurizio Gismondi; Giovanni Prosdocimo & Valentina de
Belvis, Acute Bilateral Vitreo-retinal Hemorrhages Following Oxygen-ozone Therapy for
Lumbar Disc Herniation. American Journal of Opthalmology 138: 175-177, 2004. (abstract)
Marchetti, D. & G. La Monaca, An unexpected death during oxygen-ozone therapy. American
Journal of Forensic Medicine and Pathology 21: 144-147, 2000. (abstract)
Mayer, C.; M. Soyka & D. Naber, Paranoid-halluzinatorische Psychose bei einem HIV-infizierten
Patienten unter Ozontherapie. Nervenarzt 62: 194-197, 1991. (PubMed)
Preclinical studies
Effect of ozone on cytokines and immunity: In vitro studies
Bocci, Velio & Luana Paulesu, Studies on the biological effects of ozone: 1. Induction of interferon
on human leucocytes. Haematologica 75: 510-515, 1990. (abstract)Bocci, Velio; Enrico Luzzi; Fausto Corradeschi; Luana Paulesu & Anna Di Stefano, Studies on the
biological effects of ozone: 3. An attempt to define conditions for optimal induction of
cytokines. Lymphokine and Cytokine Research 12: 121-126, 1993. (abstract)
Bocci, V.; E. Luzzi.; F. Corradeschi & S. Silvestri, Studies on the biological effects of ozone: 6.
Production of transforming growth factor 1 by human blood after ozone treatment. Journal of
Biological Regulators and Homeostatic Agents 8: 108-112, 1994. (abstract)
Bocci, V.; G. Valacchi; F. Corradeschi; C. Aldinucci; S. Silvestri; E. Paccagnini & R. Gerli, Studies
on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after
exposure of human blood to ozone. Journal of Biological Regulators and Homeostatic
Agents 12: 67-75, 1998. (abstract)
Bocci, V.; G. Valacchi; F. Corradeschi & G. Fanetti, Studies on the biological effects of ozone: 8.
Effects on the total antioxidant status and on interleukin-8 production. Mediators of
Inflammation 7: 313-317, 1998. (abstract)
Bocci, V.; G. Valacchi; R. Rossi; D. Giustarini; E. Paccagnini; A. M. Pucci & P. Di Siplicio,
Studies on the biological effects of ozone: 9. Effects of ozone on human platelets. Platelets
10: 110-116, 1999. (abstract)
Hoffmann; Allhard & Renate Viebahn, The Influence of Ozone on 2,3-Diphosphoglycerate
Synthesis in Red Blood Cell Concentrates. In: Proceedings of the 15th Ozone World
Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.),
Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
Larini, A.; L. Bianchi & V. Bocci, The Ozone Tolerance: I) Enhancement of Antioxidant Enzymes
is Ozone Dose-dependent in Jurkat Cells. Free Radical Research 37: 1163-1168, 2003.
(abstract)
Larini, A. & V. Bocci., Effects of ozone on isolated peripheral blood mononuclear cells. Toxicology
in Vitro 19: 55-61, 2005. (abstract)
Los, Marek; Dröge Wulf; Kirstin Stricker; Patrick A. Baeuerl & Klaus Schulze-Osthoff, Hydrogen
Peroxide as a potent activator of T lymphocyte functions. European Journal of Immunology
25: 159-165, 1995. (abstract)
Paulesu, Luana; Enrico Luzzi & Velio Bocci, Studies on the Biological Effects of Ozone: 2.
Induction of Tumor Necrosis Factor (TNF-) on Human Leucocytes. Lymphokine and
Cytokine Research 10: 409-412, 1991. (abstract)
Shizova, E. N.; A. D. Nozdrachev & V. I. Tsirkin, Characteristics of the Responses of Smooth
Muscles of the Uterus, Coronary Artery, and Trachea to Ozone and the Ability of -
Adrenergic Receptor Sensitizers to Decrease Its -Adrenergic Blocking Effect. Doklany
Biological Sciences 390: 200-203, 2003. (PubMed)
Valacchi, G. & Velio Bocci, Studies on the biological effects of ozone: 10. Release of factors from
ozonated human platelets. Mediators of Inflammation 8: 205-209, 1999. (abstract)
Valacchi, Giuseppe & Velio Bocci, Studies on the biological effects of ozone: 11. Release of
factors from human endothelial cells. Mediators of Inflammation 9: 271-276, 2000. (abstract)
Studies on the tissue oxygention with hydrogen peroxide
Abeatici, S.; V. Laugeri & Th. de Nunno, Etude expérimentale de l'oxygénation sanguine extracorporelle par aérosol de peroxyde d'hydrogéne (H2O2). Lyon Chirurgical 55: 352-364,
1959. (PubMed)
Hollender, L.; J. Grenier; M. M. Gex & S. Mayer, Étude biochemique de l'oxygénation sanguine
par l'eau oxygénée (H2O2). Son intérét en transfusion intra-artérielle. Lyon Chirurgical 53:
58-68, 1957. (PubMed)
Lorincz, A. L.; J. J. Jacoby & H. M. Livingstone, Studies on the parenteral administration of
hydrogen peroxide. Anesthesiology 9: 162.174, 1948.
MacNaughton, James I., Regional oxygenation and radiotherapy: a study of the degradation of
infused hydrogen peroxide. I. Infusate mixing. International Journal of Radiation Biology
19: 405-413, 1971. (PubMed)MacNaughton, James I., Regional oxygenation and radiotherapy: a study of the degradation of
infused hydrogen peroxide. I.measurement of decomposition of H2O2
infused into flowing
blood.. International Journal of Radiation Biology 19: 415-426, 1971.
White, D. C. & P. R. Teasdale, The oxygenation of blood by hydrogen peroxide: in vitro studies.
British Journal of Anaesthesia 38: 339-344, 1966. (PubMed)
Studies on the ozone/H2O2 action against various pathologies
HIV
Baggs, Albert C., Are Worry-free transfusions just a whiff of ozone away? Canadian Medical
Association Journal 148: 1155-1160, 1993.
Carpendale, Michael T. F. & Joel K. Freeberg, Ozone inactives HIV at noncytotoxic
concentrations. Antiviral Research 16: 281-292, 1991. (abstract)
Wells, Keith H.; Joseph Latino; Jerrie Gavalchin & Bernard J. Poiesz, Inactivation of Human
Immunodeficiency Virus Type 1 by Ozone In Vitro. Blood 78: 1882-1890, 1991. (pdf full
text, abstract)
Malaria
Dockrell, Hazel M. & John H. L. Playfair, Killing of Blood-Stage Murine Malaria Parasites by
Hydrogen Peroxide. Infection and Immunity 39: 456-459, 1983. (full text)
Lell. Bertrand; Renate Viebahn & Peter G. Kremsner, The Activity of Ozone Against Plasmodium
Falciparum. Ozone: Science & Engineering 23: 89-93, 2001.
Viebahn-Hänsler, R.; B. Lell & P. G. Kremsner, The Effect of Ozone on Plasmodium FalciparumInfected Red Blood Cells. In: Proceedings of the 15th Ozone World Congress, 11th - 15th
September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd,
Ealing, London, UK, 2001.
Oral pathologies
Arita, M.; M. Nagayoshi; T. Fukuizumi; T. Okinaga; S. Masumi; M. Morikawa; Y. Kakinoki & T.
Nishihara, Microbicidal efficacy of ozonated water against Candida albicans adhering to
acrylic denture plates. Oral Microbiology and Immunology 20: 206-210, 2005. (abstract)
da Silva de Faria, Ivan; Mariko Ueno; Cristiane Yumi Koga-Ito; Wilfredo Irrazabal Urruchi; Ivan
Balducci & Antonio Olavo Cardoso Jorge, Effects of ozonated water on Candida albicans
oral isolates. Brazilian Journal of Oral Science 4(14): 783-786, 2005.
Filippi, A.; F. Tilkes; E. G. Beck & H. Kirschner, Wasserdesinfektion zahnärztlicher
Behandlungsenheiten durch Ozon. Deutsche Zanhnärztliche Zeitschrift 46: 485-487, 1991.
(abstract)
Filippi, A., Water Disinfection of Dental Units using Ozone - Microbiological Results after 11
Years and Technical Problems. Ozone: Science & Engineering 24: 479-483, 2002.
Murakami, Hiroshi; Shigemitsu Sakuma; Kentarou Nakamura; Yutaka Ito; Masami Hattori;
Akihiro Asai; Toshihide Naguchi; Hatsuhiko Maeda; Yoichiro Kameyama; Yoshihiro
Kimura; Toru Nagao; Tatsushi Kawai & Jiro Hasegawa, Disinfection of Removable Dentures
Using Ozone. Dental Materials Journal 15(2): 220-225, 1996. (abstract)
Murakami, Hiroshi; Miho Mizuguochi; Masami Hattori; Yutaka Ito; Tatsushi Kawai & Jiro
Hasegawa, Effect of Denture Cleaner using Ozone against Methicillin-resistant
Staphylococcus aureus and E. coli T1 Phage. Dental Materials Journal 21(1): 53-60, 2002.
(abstract)
Nagayoshi, Masato; Chiaki Kitamura; Takaki Fukuizumi; Tatsuji Nishihara & Masamichi
Terashita, Antimicrobial Effect of Ozonated Water on Bacteria Invading Dental Tubules.
Journal of Endodontics 30: 778-781, 2004. (abstract)
Nagoyoshi, M.; T. Fukuizumi; T. Kitamura; J. Yano; M. Terashita & T. Nishihara, Efficacy of
ozone on survival and permeability of oral microorganisms. Oral Microbiology and
Immunology 19: 240-246, 2004. (abstract/full text PDF)
Rimoldi, Fabio; Liviu Steier & Wolfgang Pfister, Antibakterielle Wirkung von Ozon-aktiviertem
Natriumhypochlorit zur Wurzelkanaldesinfektion. Endodontie Journal 4/2005, 19-23, 2005.
Eye infectionsGundarova, R. A.; I. P. Khoroshilova-Maslova; G. G. Bordiugova; L. V. Ilatovskaia & I. M.
Lapina, [Experimental validation of using ozonized physiological solutions in intraocular
infection]. Vestnik oftalmologii (1996 Sep-Oct), 112(5), 9-11. [Written in Russian]
(abstract)
Kashiwagi, Kenji; Katsuya Saito; You-Dong Wang; Hiroshi Takahashi; Kiyotaka Ishijima &
Shigeo Tsukahara, Safety of ozonated Solution as an Antiseptic of the Ocular Surface prior
to Opthalmic Surgery. Opthalmologica 215: 351-356, 2001. (abstract)
Lake, Jonathan Clive; Sergio Felberg; Gustavo Ricci Malavazzi; Denise Atique Goulart; Maria
Christina Nishiwaki-Dantas & Paulo Elias Correa Dantas, Efeito Terapêutico da aplicacão
intra-ocular de ozônio em modelo experimental de endoftalmite por Staphylococcus
epidermidis em coelhos. Arquivos Brasileiros de Oftalmologia 67(4): 575-579, 2004. (Full
text PDF)
Takahashi, Hiroshi; Chiaki Fujimoto; Hironori Matsui; Tsutomu Igarashi; Toshihiko Shiwa;
Kunitoshi Ohara & Tohru Sugita, Anterior chamber irrigation with an ozonated solution as
prophylaxis against infectious endophthalmitis. Journal of Cataract & Refractive Surgery 30:
1773-1780, 2004. (abstract)
Wound infections
Gehring, W.; J. Glutsch; U. Schönian; M. Gehse & M. Gloor, Vergleichende Untersuchung über
die Wirkung verschiedener Antiseptika und der Ozonbegasung auf Ulcus cruris-übliche
Keime. Zeitschrift für Hautkrankheiten 65: 746-750, 1990. (abstract)
Studies on the ozone/H2O2 action against cancer cells
Karlic, H.; H. Kucera; M. Metka; M. Schönbauer & G. Söregi, Zur Wirkung von Ozon und
ioniserender Strahlung am In-vitro-Modell - eine Pilotstudie an vier gynakologischen
Tumoren. Strahlentherapie und Onkologie 163: 37-42, 1987. (abstract)
Sachsenmaier, Wilhelm; Wilhelmine Siebs & Tjong-An Tan, Wirkung von Ozon auf
Mäuseascitestumorzellen und auf Hühnerfibroblasten in der Gewebekultur. Zeitschrift für
Krebsforschung 67: 113-126, 1965.
Samoszuk, Michael K.; Claudia Rietveld; Farnoush Gidanian & Arne Petersen, In-Vitro Sensitivity
of Hodgins Disease to Hydrogen Peroxide Toxicity. Cancer 63: 2111-2114, 1989. (abstract)
Sweet, Frederick; Ming-Shian Kao; Song-Chiau D. Lee; Will L. Hagar & Wileen E. Sweet, Ozone
Selectively Inhibits Growth of Human Cancer Cells. Science 209: 931-933, 1980. (abstract)
Symons, M. C. R., S. Rusakiewicz; R. C. Rees & S. I. Ahmad, Hydrogen peroxide: a potent
cytotoxic agent effective in causing cellular damage and used in the possible treatment for
certain tumours. Medical hypotheses 57(1): 56-58, 2001. (abstract)
Washüttl, J.; R. Viebahn & I. Steier, The influence Of ozone On Tumor Tissue In Comparison With
Healthy Tissue (in vitro). Ozone: Science & Engineering 12(1): 65-72, 1990.
Zänker, Kurt S. & Ronald Kroczek, In vitro Synergestic Activity of 5-Fluorouracil with Low-Dose
Ozone against a Chemoresistant Tumor Cell Line and Fresh Human Tumor Cells.
Chemotherapy 36: 147-154, 1990. (abstract)
Preclinical ozone studies in dentistry
AbuNaba’a, Layla; Hisham Al Shorman & Edward Lynch, Use of Fissure Sealants over Ozone
Treated Occlusal Surfaces. In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp.
143-154, Quintessence Publishing, UK, 2004.
Baysan, A.; R. Whiley & E. Lynch, Anti-microbial effects of a novel ozone generating device on
micro-organisms associated with primary root carious lesions. Caries Research 34: 498-501,
2000. (abstract)
Baysan, Aylin & Edward lynch, Antimicrobial Effects of Ozone on Caries, In: Ozone: The
Revolution in Dentistry, Edward Lynch ed., pp. 165-172, Quintessence Publishing, UK,
2004.Campbell, Debbie; Leo Cunningham; David Hussey; Conor Armstrong; Kathleen Teretty &
Edward Lynch, The Effect of Ozone on the Bond Strengths and Surface Hardness of Some
Commonly Used Restorative Materials in Dental Practice, In: Ozone: The Revolution in
Dentistry, Edward Lynch ed., pp. 197-198, Quintessence Publishing, UK, 2004.
Grootveld, Martin; Cristopher Silwood; Julia Sim; Navaede Siddiqiu; Andrew Claxon & Edward
Lynch, Safety Aspects regarding the Therapeutic Applications of Ozone and Ozonated
Culinary Oils in Medicine and Dentistry, In: Ozone: The Revolution in Dentistry, Edward
Lynch ed., pp. 31-38, Quintessence Publishing, UK, 2004.
Grootveld, Martin; Cristopher Silwood; Julia Sim; Navaede Siddiqiu; Andrew Claxon & Edward
Lynch, High Resolution NMR Investigations of the Mechanisms of Action of ozone in the
Oral Environment: Oxidative Consumption of Salivary, Plaque and Carious Dentine
Biomolecules, In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 39-48,
Quintessence Publishing, UK, 2004.
Holmes, Julian & Edward Lynch, Equipment Available to Deliver Ozone in Dentistry, In: Ozone:
The Revolution in Dentistry, Edward Lynch ed., pp. 57-65, Quintessence Publishing, UK,
2004.
Lussi, Adrian & Paola Francescut, Use of DIADNOdent in Detecting and Monitoring Caries
Lesions and Residual Caries for Ozone Treatment, In: Ozone: The Revolution in Dentistry,
Edward Lynch ed., pp. 49-56, Quintessence Publishing, UK, 2004.
Abstracts
Abu-Naba’a, L., H. Al Shorman & E. Lynch, The Effect of ozone Application on Fissure Caries
QLF Readings [abstract]. Journal of Dental Research 81(Spec Iss A): A-386, 2002.
Baysan, A; R. Whiley & E. Lynch, The Effect of a Novel Antibacterial Ozone-Generating Device
on Microflora from Primary Root Caries ex vivo [abstract]. Caries Research 32: 300, 1998.
Campbell, D.; D. L. Hussey; L. Cunningham & E. Lynch, Effect of Ozone on Surface Hardness of
Restorative Materials [abstract]. Journal of Dental Research 82(Spec Iss B): B-262, 2003.
Chang, H. H.; C. Fulton & E. Lynch, Antimicrobial Efficacy of Ozone on Enterococcus faecalis
[abstract]. Journal of Dental Research 82(Spec Iss B): B-220, 2003.
Claxson, A.; C. Smith; M. Turner; C. Silwood; E. Lynch & M. Grootveld, Oxidative Modification
of Salivary Biomolecules with Therapeutic Levels of Ozone [abstract]. Journal of Dental
Research 81(Spec Iss A): A-502, 2002.
Grootveld, M.; E. Lynch; B. Mills; C. Smith; A. Baysan & C. J. Silwood, Therapeutic Oxidation of
Human Plaque Biomolecules by an Anti-bacterial Ozone Generating Device [abstract].
Journal of Dental Research 80(4): 1178, 2001.
Holmes, J., Management of volatile sulphur compounds with ozone [abstract]. Oral Diseases 11(3):
119-120, 2005.
Lynch, E.; A. Baysan; C. J. Silwood & M. Grootveld, Therapeutic Salivary Oxidising Activity of a
Novel Anti-bacterial Ozone-generating Device [abstract]. Journal of Dental Research
77(IADR Abstracts): 780, 1998.
Lynch, E.; C. Smith; A. Baysan; C. J. Silwood; B. Mills & M. Grootveld, Salivary Oxidising
Activity of a Novel Anti-bacterial Ozone-generating Device [abstract]. Journal of Dental
Research 80(4): 1159, 2001.
Lynch, E.; A. Baysan; C. J. Silwood; B. Mills & M. Grootveld, Oxidation of Root Caries
Biomolecules by an Anti-bacterial Ozone-Generating Device [abstract]. Journal of Dental
Research 80(AADR Abstracts): 1159, 2001.
Smith, C.; E. Lynch; A. Baysan; C. J. Silwood; B. Mills & M. Grootveld, Oxidative consumption
of Root Caries Biomolecules by an Anti-bacterial Ozone-Generating Device [abstract].
Journal of Dental Research 80(4): 1178, 2001.
Turner, M.; M. Grootveld; C. Silwood & E. Lynch, Oxidative Consumption of Biomolecules by
Therapeutic Levels of Ozone [abstract]. Journal of Dental Research 81(Spec Iss A): A-272,
2002.
Studies on the protective effects of ozone/H2O2 oxidative preconditioningAjamieh, Hussam; Nelson Merino; Eduardo Candelario-Jalil; Silvia Menéndez; Gregorio MartinezSanchez; Lamberto Re; Attilia Giuliani & Olga Sonia León, Similar protective effect of
ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury.
Pharmacological Research 45: 333-339, 2002. (abstract)
Ajamieh, Hussam Hassan; Silvia Menéndez; Nelson Merino; Gregorio Martinez-Sanchez; L. Re &
Olga S. León, Ischemic and Ozone Oxidative Preconditioning in the Protection Against
Hepatic Ischemic-Reperfusion Injury. Ozone: Science & Engineering 25: 241-250, 2003.
(abstract)
Ajamieh, H. H.; S. Menéndez; G. Martínez-Sánchez; E. Candelario-Jalil; L. Re; A. Giuliani & Olga
Sonia Léon Fernández, Effects of ozone oxidative preconditioning on nitric oxide generation
and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver
International 24: 55-62, 2004. (abstract)
Ajamieh, Hussam H.; Jorge Berlanga; Nelson Merino; Gregorio M. Sánchez; Anna M. Carmona;
Silvia M. Cepero; Atilia Giuliani; Lamberto Re & Olga S. León, Role of protein synthesis in
the protection conferred by ozone-oxidative-preconditioning in hepatic
ischaemia/reperfusion. Transplant International 18: 604-612, 2005. (abstract)
Al-Dalain, Said Mohammed; Gregorio Martínez; Eduardo Candelario-Jalil; Silvia Menéndez;
Lamberto Re; Attilia Giuliani & Olga Sonia León, Ozone treatment reduces markers of
oxidative and endothelial damage in an experimental diabetes model in rats.
Pharmacological Research 44: 391-396, 2001. (abstract)
Barber, Ernesto; Silvia A. Menéndez; María Ofelia; Nelson Merino & José Luis Calunga,
Morphological and functional renal study in kidneys of pretreated rats with ozone and
submitted to warm ischemia. Revista CENIC Ciencias Biológicas 29: 178-180, 1998.
Barber, E.; S. Menéndez; O. S. León; M. O. Barber; N. Merino; J. L. Calunga; E. Cruz & V. Bocci,
Prevention of renal injury after induction of ozone tolerance in rats submitted to warm
ischaemia. Mediators of Inflammation 8: 37-41, 1999. (abstract)
Bette, Michael; Rolf M. Nüsing; Reinier Mutters; Zullyt B. Zamora; Silvia Menendez & Siegfried
Schulz, Efficiency of Tazobactam/Piperacillin in lethal peritonitis is enhanced after
preconditioning of rats with O3
/O2
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Borrego, Aluet; Zullyt B. Zamora; Ricardo González; Cheyla Romay; Silvia Menéndez; Frank
Hernández; Teresita montero & Enys Rojas, Protection by ozone preconditioning is mediated
by the antioxidant system in cisplatin induced nephrotoxicity in rats, Mediators of
Inflammation 13: 13-19, 2004. (abstract)
Calunga, José Luis; Silvia Menéndez; Ernesto Barber; Nelson Merino & Eduardo Cruz, Ozone
Biological Response in Kidneys of Rats Submitted to Warm Ischemia. Ozone: Science &
Engineering 25: 233-240, 2003. (abstract)
Calunga, José Luis; Merien Bello; Manuel Chaple; Ernesto Barber; Silvia Menéndez & Nelson
Merino, Ozonoterapia en la glomerulonefritis tóxica experimental por adriamicina. Revista
Cubana de Investigaciones Biomédicas 23: 139-143, 2004. (full text, PDF)
Calunga, José Luis; Zullyt B. Zamora; Aluet Borrego; Sirahí del Río; Ernesto Barber; Frank
Hernández; Teresita Montero & Dunia Taboada, Ozone Therapy on Rats Submitted to
Subtotal Nephrectomy: Role of Antioxidant System. Mediators of Inflammation 2005(4):
221-227, 2005. (abstract)
Candelario-Jalil; E.; S. Mohammed Al-Dalain; O. S. León Fernández; S. Menéndez; G. PérezDavison; N. Merino; S. Sam & H. H. Ajamieh, Oxidative Preconditioning Affords Protection
Against Carbon Tetrachloride-induced Glycogen Depletion and Oxidative Stress in Rats.
Journal of Applied Toxicology 21: 297-301, 2001. (abstract)
Korolev, B. A.; G. A. Boyarinov; A. N. Monakhov; N. A. Shvets; S. P. Peretiagin; A. B. Korolev;
O. I. Kushnikova & A. D. Safonova, [Metabolism and ultrastructure of the myocardium in
protection of the heart from ischaemia by an ozonized cardioplegic solution.] Grudnaia
khirurgiia 1983 (Nov-Dec), (6), 27-31. [Written in Russian]
Leon, O. S.; S. Menendez; N. Merino; R. Castillo; S. Sam; L. Perez; E. Cruz & V. Bocci, Ozone
oxidative preconditioning: A protection against cellular damage by free radicals. Mediators
of Inflammation 7: 289-295, 1998. (abstract)León, Olga Sonia; Silvia Menéndez; Nelson Merino; Rodolfo López; Rúben Castillo, Susana Sam;
Lisett Pérez; Eduardo Cruz; Firah Jouseph & Amelia Fernández, Influencia del
preacondicionamiento oxidativo con ozono sobre los niveles de calcio. Revista CENIC
Ciencias Biológicas 29: 134-136, 1998.
Miyachi, Y., Acute mild hypothermia caused by a low dose of X-irradiation induces a protective
effect against mid-lethal doses of X-rays, and a low level concentration of ozone may act as a
radiomimetic. British Journal of Radiology 73: 298-304, 2000. (abstract/full text PDF)
Schulz, S.; Z. Z. Rodriguez; R. Mutters; S. Menendez & M. Bette, Repetitive Pneumoperitoneum
with Ozonized Oxygen as a Preventive in Lethal Polymicrobial Sepsis in Rats. European
Surgical Research 35: 26-34, 2003. (abstract/full text PDF)
Torossian, A., S. Ruehlmann; L. Eberhart; M. Middeke; H. Wulf & A. Bauhofer, Pre-treatment
with ozonized oxygen (O3) aggravates inflammation in septic rats. Inflammation Research
53(2. Suppl): S122-S125, 2004. (abstract)
Tremblay, J.; H. Chen; J. Peng; J. Kunes; M. D. Vu; S. D. Sarkissian; D. DeBlois; A. E. Bolton; L.
Gaboury; V. Marshansky; E. Gouadon & P. Hamet, Renal ischemia-reperfusion injury in the
rat is prevented by a novel immune modulation therapy. Transplantation 74: 1425-1433,
2002. (abstract)
Yaguchi, Yasuhiro; Hiroshi Satoh; Nobuyuki Wakahara; Hideki Katoh; Akihiko Uehara; Hajime
Terada; Yutaka Fujise & Hideharu Hayashi, Protective effects of hydrogen peroxide against
ischemia/reperfusion injury in perfused rat hearts. Circulation Journal 67: 253-258, 2003.
(abstract)
Zamora, Zullyt B.; José Turrent; Silvia Menéndez & Ana Carballo, Anafilaxia cutánea pasiva en
ratas usando suero de ratones previamente tratados con ozono mediante insuflación rectal.
Revista CENIC Ciencias Biológicas 29: 125-127, 1998.
Zamora, Zullyt B.; S. Menéndez; M. Bette; R. Mutters; S. Hoffmann & S. Shulz, Ozone
Prophylactic Effect and Antibiotics as a Modulator of Inflammatory Septic process in Rats.
In: Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical
Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
Zamora, Zullyt B.; Aluet Borrego; Orlay Y. Lopez; Rene Delgado; Silvia Menendez; Siegfried
Schulz & Frank Hernandez, Inhibition of tumor necrosis factor-alpha release during
endotoxic shock by ozone oxidative preconditioning in mice. Arzneimittel Forschung 54:
906-909, 2004. (abstract)
Zamora, Zullyt B.; Aluet Borrego; Orlay Y. López; René Delgado; Ricardo González; Silvia
Menéndez; Frank Hernández & Siegfried Schulz, Effects of Ozone Oxidative
Preconditioning on TNF-Release and Antioxidant-Prooxidant Intracellular Balance in Mice
During Entotoxic Shock. Mediators of Inflammation 2005(1): 16-22, 2005. (abstract)
Studies on the effects of ozone on the cellular energy metabolism
Akioka, Kenichiro; Rinji Shiratori; Yoshiro Kaneko & Setsuro Ogawa, Mechanism of action of
ozone in maintaining energy metabolism in hemorrhagic shock. Nihon University Journal of
Medicine 44: 123-133, 2002. (abstract)
Kontorschikova, Claudia N.; Irina E. Okrut & Julia R. Yefremenko, Ozone as a Regulator of
Physiological Processes in the Organism. In: Proceedings of the 15th Ozone World
Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.),
Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
Mukhina, Irina V.; Ludmila B. Snopova; Kate V. Dudina; Roman D. Lapshin & Natalya N.
Prodanetz, The Influence of ozone on the brain oxidation-reduction enzyme activity in
normal condition and postresuscitation period. In: Proceedings of the 15th Ozone World
Congress, 11th - 15th September 2001, Medical Therapy Conference (IOA 2001, Ed.),
Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
Shimizu, Nobutaka & Rinji Shiratori, Effects of ozone administration on cerebral and hepatic tissue
metabolism in hemorrhagic shock. Nihon University Journal of Medicine 41: 325-338, 1999.
(abstract)Blood/Tissue oxygenation with ozone/H2O2: Animal Studies
Ackerman, Norman B. & Floyd B. Brinkley, Comparison of effects on tissue oxygenation of
hyperbaric oxygen and intravascular hydrogen peroxide. Surgery 63(2): 285-290, 1968.
Almazov, V.A.; K. N. Kontorshchikova & V. S. Gurevich, [Lipid peroxidation and blood gas
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Ozone/H2O2 therapy in cancer: Animal studies
Goncharova, T. A. & K. N. Kontorshchikova, [Effect of the ozonized physiologic solution on
biochemical parameters of liver during neoplasia]. Biulleten Eksperimentalnoi Biologii i
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Grundner, H.-G.; E. Bauer; G. Tramer & E. Utesch, Tierexperimentelle Untersuchungen über die
Anwendung von Ozon auf unbestrahlte und bestrahlte Tumoren: I. Intravenöse
Ozonbehandlung des Crocker-Sarkoms 180 und des Erlich-Karzinoms der weißen Maus.
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Grundner, H.-G. & U. Erler, Tierexperimentelle Untersuchungen über die Anwendung von Ozon
auf unbestrahlte und bestrahlte Tumoren: II. Erlich-Asziteskarzinom in vivo. Strahlentherapie
151(6): 522-529, 1976. (abstract)
Grundner, H. -G., Tierexperimentelle Untersuchungen über die Anwendung von Ozon auf
ubestrhlte und bestrahlte Tumoren: III. Erlich-Aszites-Karzinomzellen in vitro.
Strahlentherapie 151: 480-486, 1976. (abstract)
Hernuss, P.; E. Müller-Tyl & W. Seitz, Strahlensensibilisierender Effekt von Ozon im Tierversuch.
Strahlentherapie 147: 91-96, 1974.
Holman, R. A., A Method of destroying a Malignant Rat Tumour in vivo. Nature 159: 1033, 1957.
(PubMed)
Kaibara, Nobuaki; Toshihiko Ikeda; Takao Hattori & Kiyoshi Inokuchi, Experimental Studies on
Enhancing the Therapeutic Effect of Mitomycin-C with Hydrogen Peroxide. Japanese
Journal of Experimental Medicine 41: 323-329, 1971. (PubMed)
Nathan, Carl F. & Zanvil A. Cohn, Antitumor effects of hydrogen peroxide in vivo. Journal of
Experimental Medicine 154: 1539-1553, 1981. (full text PDF)
Rodríguez, Yumilda; Silvia Menéndez; José Luis Bello; Elaine Matos; Adria Espinosa; José
Turrent; Lisbett Pimienta; Sonia Ramos & Ciro Otero, Actividad antitumoral del ozono.
Revista CENIC Ciencias Biológicas 29: 196-199, 1998. (abstract)
Scherbatyuk, Tatiana; Svetlana Alekhina; Vladimir Romanov & Irina Ivanova, Expermental
Research of Biological Effects of Ozone Therapy and radiation Therapy in Cancer Animals.
In: Proceedings of the 15th Ozone World Congress, 11th - 15th September 2001, Medical
Therapy Conference (IOA 2001, Ed.), Speedprint Macmedia Ltd, Ealing, London, UK, 2001.
Sugiura, K., Effect of hydrogen peroxide on transplanted rat and mouse tumors. Nature 182: 1310,
1958. (PubMed)
Teske, H.-J.; B. Badenberg & W. Hoffmann, Tierexperimentelle Untersuchungen über die
Ozonwirkung auf Tumorwachstum und Bestrahlungseffekt. Strahlentherapie 145: 155-160,
1973. (PubMed)
Ozone/H2O2 therapy in various pathologies: Animal Studies
Babaei, Saeid; Duncan J, Stewart; Pierre Picard & Juan Carlos Monge, Effects of VasoCare therapy
on the initiation and progression of atherosclerosis. Atherosclerosis 162: 45-53, 2002.
(abstract)Boisseau, René, De l'emploi du peroxyde d'hydrogène en oxygénothérapie d'urgence.
Experimentation sur le lapin: Innocuité et efficacité des injections d'eau oxygénée diluée.
Bulletin de l'Academie nationale de medecine 151(7): 134-139, 1967. (PubMed)
Bradley jr., Bruce E.; Neylan A. Vedros; Alfred J. Defalco; Dexter W. Lawson; Gordon C.
Vineyard & Harold C. Urschel, The Effect of intra-arterial hydrogen peroxide in rabbits
infected with Clostridum Perfringens. Journal of Trauma 5(6): 799-804, 1965. (PubMed)
Chang, Johnson D. S.; Hou-Shan Lu; Ye-Fun Chang & David Wang, Ameliorative effect of ozone
on cytokine production in mice injected with human rheumatoid arthritis synovial fibroblast
cells. Rheumatology International 26:142-151, 2005. (abstract)
Eliakim, Rami; Fanny Karmeli; Danny Rachmilewitz; Patricia Cohen & Ari Zimran, Ozone Enema:
A Model of Microscopic Colitis in Rats. Digestive Diseases and Sciences 46: 2515-2520,
2001. (abstract)
Finney, James W.; George A. Balla; George J. Race & John T. Mallams, Peripheral Blood Changes
in Humans and Experimental Animals Following the Infusion of Hydrogen Peroxide into the
Carotid Artery. Angiology 16: 62-66, 1965.
Finney, J. W.; H. C. Urschel; G. A. Balla; G. J. Race; B. E. Jay; H. P. Pingree; H. L. Dorman & J.
T. Mallams, Protection of the ischemic heart with DMSO alone or DMSO with hydrogen
peroxide. Annals of the New York Academy of Sciences 141: 231-241, 1967. (PubMed)
Finney, J. W.; S. Haberman; G. J. Race; G. A. Balla & J. T. Mallams, Local and Regional
Applications of Hydrogen Peroxide in the Control of Clostridial Myositis in Rabbits. Journal
of Bacteriology 93: 1430-1437, 1967. (full text)
Fish, Jason; Jeff Healy; Rob Gensure; Ella Choe & John Ferrara, Effect of peritoneal and gastric
irrigation with ozonated saline on arterial and venous blood gas values. Life Sciences 53:
1867-1872, 1993. (abstract)
Gell, A. O. Pérez; M. Lastre; M. Gómez; S. Menéndez & J. L. Aloma, Ozonoterapia en gerbils
infectados experimentalmente con giardia lamblia. Revista CENIC Ciencias Biológicas 20(1-
3): 55-58, 1989.
González, Addys; Ernesto Basabe; Nelson Merino; Silvia Menéndez; Magalys Gómez & Amelia
Capote, Evaluación histopatológica del oído interno de curieles sometidos a toxicidad por
estroptomicina y tratados con ozono. Revista CENIC Ciencias Biológicas 29: 189-191, 1998.
González, Ricardo; Aluet Borrego, Zullyt Zamora; Cheyla Romay; Frank Hernández; Silvia
Menéndez; Teresita Montero & Enis Rojas, Reversion by ozone treatment of acute
nephrotoxicity induced by cisplatin in rats. Mediators if Inflammation 13(5/6): 307-312,
2004. (abstract)
Gusak, V. K.; L. I. Klioner; V. E. Belinsky; V. G. Shlopov; Yu. V. Danilov & E. A. Zhadko,
[Possibilities of the use of weak hydrogen peroxide solutions in treatment of ischemia of the
lower extremities in experiment]. Klinikheskaja Hirurgija No7: 31-33, 1986. [ Written in
Russian] (PubMed)
Hernández, F.; M. Noa; S. Menéndez & M. Gómez, Estudio de los lipidos de animales de
experimentacion sometidos a ozonoterapia. Revista CENIC Ciencias Biológicas 20(1-3): 48-
53, 1989.
Hernández, Frank; Miriam Noa; Lydia Armas & Silvia Menéndez, Efecto de la ozonoterapia
intramuscular sobre el metabolismo de los lipidos de ratas normocolesterolemicas. Revista
Cubana de Investigaciones Biomédicas 9(1): 40-47, 1990.
Iakovleva, E.I.; S. P. Peretiagin; K. N. Kontorshchikova; G. S. Seroglazova; N. N. Andreeva & T.
V. Dergunova, [The effect of extracorporeal treatment of blood with an ozone-oxygen
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Kapur, B. M. L. & S. C. Arya, Intra-arterial hydrogen peroxide in experimental gas-gangrene.
Indian Journal of Medical Research 55: 1281-1284, 1967. (PubMed)
Knoch, H. G. & W. Klug, [Ozone-oxygen therapy in proctology]. Terapevticheskii arkhiv 62: 93-
98, 1990. [Written in Russian] (abstract)
Kontorshchikova K.N. & T. I. Solov'eva, [Effect of ozone on intensity of lipid peroxidation in heart
tissue, isolated from clinically dead rats] Biulleten Eksperimentalnoi Biologii i Meditsiny
121(2): 161-163, 1996. [Written in Russian] (PubMed)Kontorshchikova K.N.; I. M. Solopaeva & S. P. Peretiagin, [Effect of ozone on the liver state in
experimental chronic hepatitis]. Biulleten Eksperimentalnoi Biologii i Meditsiny 122(8): 238-
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Korolev, B. A.; G. A. Boyarinov; A. N. Monakhov; N. A. Shvets; S. P. Peretiagin; A. B. Korolev;
O. I. Kushnikova & A. D. Safonova, [Metabolism and ultrastructure of the myocardium in
the protection of the heart from ischaemia by an ozonized cardioplegic solution]. Grudnaja
Hirurgija No. 6: 27-31, 1983 [Written in Russian] (PubMed)
Kuryszko, Jan, Janusz A. Madej & Pawel Madej, Ultrastructural studies on organs of cadmiumpoisoned rats treated with oxygen-ozone mixture. Archivum Veterinarium Polonicum 35:
109-115, 1995. (abstract)
Laszczyca, Piotr; Ewa Kawka-Serwecinska; Ilona Witas; Bogdan Dolezych; Barbara Falkus; Ali
Mekail; Barbara Ziolkowska; Pawel Madej & Pawel Migua, Lipid peroxidation and activity
of antioxidative enzymes in the rat model of ozone therapy. Materia Medica Polona 28: 155-
160. 1996. (abstract)
Lelyanov, A. D.; V. I. Sergienko; N. V. Ivliev; V. V. Emel'yanov & E. D. Guseva, Effects of
Sodium Hypochlorite and Ozone on Healing of Intestinal Anastomosis in Simulated
Strangulation Colorectal Obstruction. Bulletin of Experimental Biology and Medicine 137:
103-105, 2004. (abstract)
Montero, Teresita; José Hurtado; Patricio Moreno & Pablo Cabrera, Sistema de puntuación del
daño múltiple de órganos en un modelo de quemadura tratado con aloe b, ozono y factor de
crecimiento epidérmico. Revista Cubana de Medicina Militar 33(3), 2004. (full text)
Olson, Richard D. & Robert C. Boerth, Hydrogen peroxide: benefical effects in rabbits following
acute coronary occlusion. American Journal of Physiology 234: H28-H34, 1978. (PubMed)
Ortega, R. & R. Pérez, Aplicacion de la ozonoterapia en la gastroenteritis hemorragica del perro.
Revista CENIC Ciencias Biológicas 20(1-3): 53-55, 1989.
Ozmen, V.; W. O. Thomas; J. T. Healy; J. M. Fish; R. Chambers; E. Tacchi; R. L. Nichols; L. M.
Flint & J. J. Ferrera, Irrigation of the Abdominal Cavity in the Treatment of Experimentally
Induced Microbial Peritonitis: Efficacy of Ozonated Saline. American Surgeon 59: 297-303,
1993. (abstract)
Rotter, M.; H. Mittermayer & M. Kundi, Experimentelle Untersuchungen am Meerschweinchen zur
Therapie des Gasbrandes mit Ozon. Wiener Klinische Wochenschrift 86: 776-778, 1974.
(PubMed)
Schulz, S., The role of ozone/oxygen in clindamycin-associated enterocolitis in the Djungarian
hamster (Phodopus sungorus sungorus). Laboratory Animals 20: 41-48, 1986. (abstract)
Schulz, S.; M. Bette; S. Schlimme; R. Mutters; S. Hoffmann & S. Menéndez, Influence of O3
/O2
-
pneumoperitoneum as an oxidative stressor on duration of anaesthesia, loss of different
reflexes and cytokine mRNA expression. Laboratory Animals 38: 261-271, 2004. (abstract)
Stanek, G.; H. Mittermayer & M. Rotter, Weitere experimentelle Untersuchungen zur Therapie des
Gasbrandes mit Ozon und Sauerstoff. Wiener Klinische Wochenschrift 88: 141-144, 1976.
(abstract)
Steinhart; H.; S. Schulz & R. Mutters, Evaluation of ozonated oxygen in an experimental animal
model of osteomyelitis as a further option for skull -base osteomyelitis. European Archives of
Otorhinolaryngology 256: 153-157, 1999. (abstract)
Abstracts
Merin, Oler; Ari Zimran; Debbie Elstein; Gerhard Wasser; Herzl Schwalb; Dani Bitran & Shuli
Silberman, Ozone Reduces Reperfusion Injury in an Isolated Rat Heart Model [abstract].
Journal of the American College of Cardiology 41(6, suppl A): 331A, 2003.
Other animal studies
Bocci, V.; E. Boneli; G. Valacchi & E. Luzzi, Quasi-total-body exposure to an oxygen-ozone
mixture in a sauna cabin. European Journal of Applied Physiology 80: 549-554, 1999.
(abstract)Bocci, Velio; Emma Borrelli; Fausto Corradeschi & Giuseppe Valacchi, Systemic effects after
colorectal insufflation of oxygen-ozone in rabbits. International Journal of Medicine,
Biology and the Environment 28: 109-113, 2000.
Friman, M.; D. Walker; L. Eng; S. Menéndez & M. Gómez, Efecto del ozono en las celulas
endoteliales circulantes en ratas. Revista CENIC Ciencias Biológicas 20(1-3): 25-28, 1989.
Sizova, E. N.; V. I. Tsirkin & A. A. Kostjaev, [Influence of ozone on contractile activity and
chemoreactivity of uterus horns longitudal muscles of nonpregnant rat]. Rossiiskii
Fiziologicheskii Zhurnal imeni I. M. Sechenova 89: 427-435, 2003. [Written in Russian]
(abstract)
Ugarte, J. C.; R. Wong; J. Alfonzo; J. Banasco; M. Gómez; J. García; S. Menéndez; N. Ladron de
Guevara; E. Moreno; W. Román & E. Fermín, Ozone Contrast Media in Digital Renal
Angiography. Nephron 56: 332, 1990. (PubMed)
Studies on the hemotoxicity of ozone therapy
Biedunkiewicz, B.; L. Tylicki; D. Rachon; L. Hak; T. Nieweglowski; A. Chamienia; A. DebskaSlizien; J. Mysliwska & B. Rutkowski, Natural killer cell activity unaffected by ozonated
autohemotherapy in patients with end-stage renal disease on maintenance renal replacement
therapy. International Journal of Artificial Organs 27(9): 766-771, 2004. (Abstract)
Diaz, Arquímides; Milagros Garcia; Carmen Piña & Silvia Menéndez, Efecto del ozono sobre la
activación plaquetaria en pacientes con enfermedades vasculares periféricas: Informe
preliminar. Revista Cubana de Investigaciones Biomédicas 20: 42-44, 2001. (full text PDF)
Diaz, Arquímides; Milagros Garcia; Carmen Piña & Silvia Menéndez, Efecto del ozono sobre la
activación plaquetaria en pacientes diabéticos tratados con ozonoterapia: Informe preliminar.
Revista Cubana de Investigaciones Biomédicas 20: 45-47, 2001. (full text PDF)
Górnicki, Albert & Aleksander Gutsze, In vitro effects of ozone on human erythrocyte membranes:
An EPR study. Acta Biochimica Polonica 47(4): 963-971, 2000.
Margalit, Maya; Eyal Attias; Drorit Attias; Deborah Elstein; Ari Zimran & Yaacov Matzner, Effect
of ozone on neutrophil function in vitro. Clinical and Laboratory Haematology 23: 243-247,
2001. (abstract)
Shinriki, N.; T. Suzuki; K. Takama: K. Fukunaga; S. Ohgiya; K. Kubota & T. Miura,
Susceptibilities of plasma antioxidants and erythrocyte constituents to low levels of ozone.
Haematologia 29: 229-239, 1998. (abstract)
Tylicki, Leszek; Bogdan Biedunkiewicz; Tomasz Nieweglowski; Malgorzata Grabowska; Andrzej
Chamienia: Alicja Debska-Slizien & Boleslaw Rutkowski, Fistula Function and Dialysis
Adequacy During Ozonotherapy in Chronically Hemodialyzed Patients. Artificial Organs 28:
513-517, 2004. (abstract)
Tylicki, L.; S. Lizakowski; B. Biedunkiewicz; A. Skibowska; T. Nieweglowski; A. Chamienia; A.
Debska-Slizien & B. Rutkowski. Platelet function unaffected by ozonated autohaemotherapy
in chronically haemodialysed patients. Blood Coagulation & Fibrinolysis 15: 619-622, 2004.
(abstract)
Tylicki, Leszek; Bogdan Biedunkiewicz; Dominik Rachon; Tomasz Nieweglowski; Lukasz Hak;
Andrzej Chamienia: Alicja Debska-Slizien; Ewa Aleksandrowicz; Jolanta Mysliwska &
Boleslaw Rutkowski, No effects of ozonated autohemotherapy on inflammation response in
hemodialyzed patients. Mediators of Inflammation 13: 377-380, 2004. (abstract)
Zimran, Ari; Gerhard Wasser; Linda Forman; Terri Gelbart & Ernest Baeutler, Effects of Ozone on
Red Blood Cell Enzymes and Intermediates. Acta Haematologica 102: 148-151, 1999.
(abstract)
Abstracts
Luongo, C.; A. Coppola; A. Sammartino; L. Mascolo; M. Luongo & L. Coppola, Effects of
oxygen-ozone mixture on the platelet aggregation and on the haematic viscosity [abstract].
European Journal of Clinical Investigation 33(Suppl. 1): 46, 2003.Studies on the ozone therapy genotoxicity
De las Cagigas, A.; A. Pérez; S. Menéndez; M. Gómez, Estudio mutagenico del ozono por
autohemoterapia. Revista CENIC Ciencias Biológicas 20(1-3): 41-44, 1989.
Diaz, Silvia del C. & Yousy González, Frecuencia de micronúcleos en sangre periférica de
pacientes tratados con ozono. Revista Cubana de Investigaciones Biomédicas 18: 29-31,
1999. (full text PDF)
Díaz, Silvia; Jorge E. González; Yanela González & Rolando Wong, Estudio de pacientes
sometidos a ozonoterapia mediante el ensayo de electroforesis alcalina de células
individuales. Anuario de Toxicología 1: 88-92, 2001. (full text PDF)
Fernández, S. I.; C. Quinzan; S. Menéndez; M. Gómez & P. Acosta, Estudio del efecto del ozono
intratesticular sobre la espermatogenesis. Revista CENIC Ciencias Biológicas 20(1-3): 16-20,
1989.
Fernández, S. I.; C. Quinzan; S. Menéndez & M. Gómez, Estudio de posibles efectos teratogenicos
y mutagenicos en animales de experimentacion por via intraperitoneal e intramuscular.
Revista CENIC Ciencias Biológicas 20(1-3): 45-47, 1989.
Foksinski, Marek; Karol Bialkowski; Marek Skiba; Irena Ponikowska; Wlodzimierz Szmurlo &
Ryszard Olinski, Evaluation of 8-oxodeoxyguanosine, typical oxidative DNA damage, in
lymphocytes of ozone-treated arteriosclerotic patients. Mutation Research 438: 23-27, 1999.
(abstract)
Prieto, E.; L. Montejo; D. Méndez del Castillo; S. Menéndez; D. Bello; J. Johnson & E. Carvajal,
Evaluation of ozone genotoxicity by cytogenetics techniques. In: Ozone in medicine:
Proceedings of the 11
th
Ozone World Congress (Stamford, CT., International Ozone
Association, Pan American Committee) M-3-44-M-3-52, 1993. (abstract)
Other Ozone/H2O2-therapy-related toxicological studies
DeSesso, J. M.; A. L. Lavin; S. M. Hsia & R. D. Mavis, Assessment of the carcinogenicity
associated with oral exposures to hydrogen peroxide. Food and Chemical Toxicology 38:
1021-1041, 2000. (abstract)
García, R.; E. Ruiz; J. Ramos; M. Verdecia; L. A. Cuza; M. Vargas; G. Lezcano; M. A. Torres; S.
Menéndez; M. Gómez & E. Enriquez, Estudio electrocardiografico en grandes quemados
tratados por autohemoterapia con ozono. Valoracion de 20 pacientes y 37 sesiones. Revista
CENIC Ciencias Biológicas 20(1-3): 104-106, 1989.
Noa, M. F. Hernández; M. Herrera; S. Menéndez; A. Capote & C. Aguilar, Observaciones
morfologicas en ratas tratadas con ozono por via intramuscular. Revista CENIC Ciencias
Biológicas 20(1-3): 20-23, 1989.
Rodríguez, M. D.; S. Menéndez; M. Gómez; H. García & L. Eng. Estudio teratogenico del agua
ozonizada administrada intragastricamente. Revista CENIC Ciencias Biológicas 20(1-3): 11-
14, 1989.
Rodríguez, M. D.; S. Menéndez; M. Gómez & H. García, Estudio teratogenico del ozono
administrado por insuflacion rectal a ratas wistar. Revista CENIC Ciencias Biológicas 20(1-
3): 28-32, 1989.
Rodríguez, M. D.; S. Menéndez; M. Gómez; O. Ancheta; H. García; L. Eng & M. E. Ramos, Efecto
del suero ozonizado sobre embriones en cultivo. Revista CENIC Ciencias Biológicas 20(1-3):
32-37, 1989.
Suzuki, T.; M. Oizumi; J. Furuya; Y. Okamoto & S. F. Rosenstiel, Influence of ozone on oxidation
of dental alloys. International Journal of Prosthodontics 12: 179-183, 1999. (abstract)
Ozonized substances: Preclinical animal studiesLezcano, Irene; Gastón García; Gerardo Martínez; Jesús Molerio; Zullyt Zamora; Carlos
Fernández; Addys González & Daily Castañeda, Efectividad de la manteca de cacao
ozonizada para el tratamiento de la candidiasis vaginal. Revista CENIC Ciencias Biológicas
29: 206-208, 1998.
Rodrigues, Kamila Leite; Claudia Catellani Cardoso; Lucelia Regina Caputo; Jose Carlos Tavares
Carvalho; Joao Evangelista Fiorini & Jose Mauricio Schneedorf. Cicatrizing and
antimicrobial properties of an ozonized oil from sunflower seeds. Inflammopharmacology
12: 261-270, 2004. (abstract)
Rosario Barroetbeña Reyes, Ana del; Alejandro Sánchez Anta & Juan Guerra Miranda, Acción del
aceite ozonizado sobre el proceso inflamatorio en heridas de piel de animales de
experimentación. Correo Científico Médico de Holguín 6(2), 2002. (full text)
Sánchez, Alejandro; Pedro Díaz; Gloria Rodríguez; Elizaberh Leyva; Elena Díaz & Luis Borrego,
Acción del aceite ozonizado sobre la cicatrization de heridas de piel en animales de
experimentación. Revista CENIC Ciencias Biológicas 29: 181-184, 1998.
Schulz, S., Ein neues tiermodell zur integralen messung von heilvorgängen bei kleinen labortieren
am beispiel von ozonisiertem olivenöl. Deutsche Tierärztliche Wochenschrift 88: 60-64,
1981. (PubMed)
Schulz, S.; H. Schmitt; R. Obermeyer & I. Oepen, Einige Ergebnisse und therapeutische Aspekte
von ozonisiertem Olivenöl in der Veterinärdermatologie. Praktische Tierarzt 63(1): 18-33,
1982. (abstract)
Ozonized substances: Chemistry and antimicrobial properties
Díaz, Maritza; Irene Lezcano; Jesús Molerio & Frank Hernández, Spectroscopic Characterization
Of Ozonides With Biological Activity. Ozone: Science & Engineering 23: 35-40, 2001.
Díaz, Maritza F.; Nayibi Núñez; Daraisy Quincose; Wilfredo Díaz & Frank Hernández, Study of
Three Systems of Ozonized Coconut Oil. Ozone: Science & Engineering 27: 153-157, 2005.
Díaz, Maritza F; Rebeca Hernández; Goitybell Martínez; Genny Vidal; Magali Gómez; Harold
Fernández & Rafael Garcés, Comparative Study of Ozonized Olive Oil and Ozonized
Sunflower Oil. Journal of the Brazilian Chemical Society (in press, e-version available),
2006.
Harada, Taichi, Olive oil ozonide and its fungicidal quality. Bulletin of the Chemical Society of
Japan 9: 192-197, 1934.
Lezcano, Irene; Jesús Molerio; Magaly Gómez; Rolando Contreras; Gloria Roura & Wilfredo Díaz,
Actividad in vitro del OLEOZON frente a agentes etiológicos de infecciones en la piel.
Revista CENIC Ciencias Biológicas 29(3): 209-212, 1998. (abstract)
Lezcano, I.; N. Nuñez; M. Espino & M. Gómez, Antibacterial Activity of Ozonized Sunflower Oil,
Oleozón, Against Staphylococcus aureus and Staphylococcus epidermidis. Ozone: Science &
Engineering 22: 207-214, 2000.
Rainbauer, H.; J. Washüttl; I. steiner ; G. Kroyer; N. Winker & F. Streichsbier, Chemische
Untersuchungen an ozonisiertem Olivenöl. Fette Seifen Anstrichmittel 84: 188-191, 1982.
(abstract)
Sechi, L. A.; I. Lezcano; N. Nunez; M. Espim; I. Dupré; A. Pinna; P. Molicotti; G. Fadda & S.
Zanetti, Antibacterial activity of ozonized sunflower oil (Oleozon). Journal of Applied
Microbiology 90: 279-284, 2001. (abstract)
Stevens, Franklin A., The Bactericidal and Photochemical Properties of Irradiated Cod Liver Oil
and an Ozonide of Olive Oil. Journal of Bacteriology 32: 47-56, 1936. (abstract)
Streichsbier, F.; H. Rainbauer; J. Washüttl; G. Kroyer; I. Steiner & N. Winker, Mikrobiologische
Untersuchungen an ozonisiertem Olivenöl. Fette Seifen Anstrichmittel 84: 304-308, 1982.
(abstract)
Ozonized substances: Toxicology, genotoxicity and metabolismFernández, S. I.; C. Quinzan; S. Menéndez & M. Gómez, Evaluacion mutagenica del aceite
ozonizado administrado intragastricamente. Revista CENIC Ciencias Biológicas 20(1-3): 14-
16, 1989.
González, Yousy; Antonia Remigio; Zullyt Zamora & Gladys Fonseca, Ozonoterapia: Efectos
genotóxicos en sangre periférica de ratón. Revista Cubana de Investigaciónes Biomedicas 18:
37-39, 1999. (full text PDF)
Noa, M.; I. fernández; M. Herrera; S. Menéndez; A. Capote & C. Aguilar, Estudio Histologico de
vias digestivas de ratones tratados con aceite ozonizado. Revista CENIC Ciencias Biológicas
20(1-3): 23-24, 1989.
Remigio, Antonia; Yousy González; Zullyt Zamora; Gladys Fonseca & Jesús Molerio, Evaluación
genotóxica del OLEOZON mediante los ansayos de micronúcleos en médula ósea y sangre
periférica de ratón. Revista CENIC Ciencias Biológicas 29: 200-202, 1998.
Remigio, Antonia; Yousy González; Zullyt Zamora & Gladys Fonseca, Influye la ozonoterapia
sobre la médula ósea de ratones tratados? Revista Cubana de Investigaciónes Biomedicas 18:
24-26, 1999. (full text PDF)
Ozone therapy: Technique and technology
Bocci, V. & N. Di Paolo, Oxygenation-Ozonation of Blood During Extracorporeal Circulation
(EBOO). Part III: A New Medical Approach. Ozone: Science & Engineering 26: 195-205,
2004. (abstract)
Carpentier, M., Appareil pour faciliter les directes d'ozone dans les plaies chirurgicales. Presse
Medicale no.4. (14. Janvier p. 77, 1939.
Rasplicka, Den; Technical Aspects of Ozonation Equipment for Ozone Therapies. Presented:
International Oxidative Medicine Association Conference, Las Vegas, Nevada, February 23-
25, 2001.
Steinbart, Hitrud; Die Entwicklung der extracorporalen Behandlung des Blutes mit Sauerstoff, UVstrahlen und Ozon, Medizinische Klinik 55: 112-114, 1960.
Hypotheses, reviews and comments
General
Anon., Hilft die Ozontherapie? Münchener Medizinische Wochenschrift 125(39): A38, 1983.
Bocci, V., Autohemotherapy After Treatment of Blood with Ozone. A Reappraisal. Journal of
International Medical Research 22: 131-144, 1994. (abstract)
Bocci, V., Ozone as a bioregulator. Pharmacology and toxicology of ozonetherapy today. Journal
of Biological Regulators and Homeostatic Agents 10: 31-53, 1996. (abstract / PDF)
Bocci, Velio, Is Ozone Therapy Therapeutic? Perspectives in Biology and Medicine 42: 131-143,
1998.
Bocci, V., Biological and clinical effects of ozone. Has ozone therapy a future in medicine? British
Journal of Biomedical Science 56: 270-279, 1999. (abstract, full text PDF)
Bocci, V.; C. Aldinucci; E. Borrelli; F Corradeschi; A. Diadori; G. Fanetti & G. Valacchi, Ozone in
Medicine. Ozone Science & Engineering 23: 207-217, 2001. (full text, PDF)
Bocci, Velio, Ozone as Janus: this controversial gas can be either toxic or medically useful.
Mediators of Inflammation 13: 3-11, 2004. (abstract)
Bocci, Velio, How ozone Acts and how it Exerts Therapeutic Effects. In: Ozone: The Revolution in
Dentistry, Edward Lynch ed., pp. 15-22, Quintessence Publishing, UK, 2004.Di Paolo, N.; V. Bocci & E. Gaggiotti, Ozone therapy. International Journal of Artificial Organs
27: 168-175, 2004. (full text)
Di Paolo, N.; V. Bocci & E. Gaggiotti, Ozone therapy and clinical efficacy. International Journal
of Artificial Organs 27(8): 733, 2004
Di Paolo, N; E. Gaggiotti & F. Galli, Extracorporeal blood oxygenation and ozonation: clinical and
biological implications of ozone therapy. Redox Report 10(3): 121-130, 2005. (abstract)
Gorbatsevich, L. I. & N. N. Timofeev, [Intra-arterial application of hydrogen peroxide solutions
experimentally and clinically (literature review)]. Vestnik Khirurgii 108: 119-123, 1972
[Written in Russian] (PubMed)
Grootveld, Martin; Aylin Baysan; Navaede Siddiqui; Julia Sim; Christopher Silwood & Edward
Lynch, History of the Clinical Applications of Ozone. In: Ozone: The Revolution in
Dentistry, Edward Lynch ed., pp. 23-30, Quintessence Publishing, UK, 2004.
Idov I. E.; [Aspects of using ozone in medicine]. Anesteziologiia i reanimatologiia (1997 Jan-Feb),
(1), 90-94. [Written in Russian]
Kief, H., Neue Möglichkeiten in der ozontherapie. Erfahrungsheilkunde 29: 957-964, 1980.
Madej, Pawel, Zygmunt Antoszewski & Janusz A. Madej, Ozonotherapy. Materia Medica Polona
27: 53-56, 1995. (abstract)
Korabeljikov, A. I.; A. O. Ospanov & S. V. Aksenova, [Ozone in Medicine], Vestnik
Novgorodskogo Gosudartsvennogo Universiteta 1998 (No. 7). [Written in Russian]
Schoop, W., Ozontherapie. Deutche Medizinische Wochenschrift 107: 1984, 1982.
Tylicki, L. & B. Rutkowski, Ozone therapy seems to be safe, but is it really clinically effective?
International Journal of Artificial Organs 27(8): 731-732, 2004. (PubMed)
Wolff, H., Dass Ozon und seine Eigenschaften. Ärztliche Praxis 15(XIII): 909-914, 1961.
Abstracts
Bocci, V.; E. Luzzi; F. Corradeschi, L. Paulesu; A. Di Stefano; S. Silvestri & C. Aldinucci,
Development of a biological response modifiers system based upon stimulation of blood with
ozone ex vivo and reinfusion [abstract]. European Journal of Cancer 31 (suppl. 3): S32,
1995.
Richelmi, P.; L. Valdenassi & F. Bertè, New aspects of oxygen-ozone therapy [abstract]. European
Journal of Clinical Investigation 33 (1. suppl.): 44, 2003.
Negative commets and reviews (from those who don´t have any personal experience on the
ozone therapies)
CA, Questionable Methods of Cancer Management: Hydrogen Peroxide and Other
´Hyperoxygenation´ Therapies. CA: A Cancer Journal for Clinicians 43: 47-56, 1993.
Kidd, E., Sleepless in Surbiton. British Dental Journal 199(8), 485, 2005. (PubMed)
McComb, Dorothy, No reliable evidence that ozone gas stops or reverses tooth decay. EvidenceBased Dentistry 6: 34, 2005. (summary)
NICE (National Institute for Health and Clinical Excellence), HealOzone for the treatment of tooth
decay (occlusal pit and fissure caries and root caries, Technology Appraisal 92. Available
at: http://www.nice.org.uk/TA092
Richards, D., Ozone revolution? Or emperors new clothes? British Dental Journal 199(8), 485,
2005. (PubMed)
Book reviews
Hayes, K., Ozone: The revolution in dentistry. British Dental Journal 199(5): 307, 2005.
SurgeryFrantsuzov, V. N.; N. A. Efimenko; A. E: Shestopalov; A. A. Novozhilov & N. S. Kostenko, [Some
aspects of intensive care for severe forms of anaerebic nonsporeforming infection of soft
tissues]. Khirurgiia (10), 21-23, 1999. [Written in Russian] (abstract)
Viral diseases
Bocci, V., Ozonization of Blood for the Therapy of Viral Diseases and Immunodeficiencies. A.
Hypothesis. Medical Hypotheses 39: 30-34, 1992. (abstract)
Bocci, V., A reasonable approach for the treatment of HIV infection in the early phase with
ozonetherapy (autohaemotherapy). How 'inflammatory' cytokines may have a therapeutic
role. Mediators of Inflammation 3: 315-321, 1994. (abstract)
Bocci, V., Does Ozone Therapy Normalize the Cellular Redox Balance? Implications for the
Therapy of Human Immunodeficiency Virus Infection and Several Other Diseases. Medical
Hypotheses 46: 150-154, 1996. (abstract)
Sickle cell anemia and β-thalassemia
Bocci, V. & C. Aldinucci, Rational bases for using oxygen-ozonetherapy as a biological response
modifier in sicle cell anemia and -thalassemia: A therapeutic perspective. Journal of
Biological Regulators and Homeostatic Agents 18: 38-44, 2004. (abstract / Full text PDF)
Orthopedic problems
Bertoli, A. M. & G. S. Alarcón, Ozone Therapy and Lower Back Pain. American Journal of
Neuradiology 27: 471, 2006.
Bonetti, M. & M. Leonardi, Ozone Therapy and Lower Back Pain [Reply]. American Journal of
Neuradiology 27: 471, 2006.
Andreula, Cosma; Mario Muto & Marco Leonardi, Interventional spinal procedures. European
Journal of Radiology 50: 112-119, 2004. (abstract)
Gracer, R. I. & V. Bocci, Can the combination of localized "proliferative therapy" with "minor
ozonated autohemotherapy" restore the natural healing process? Medical Hypotheses 65(4):
752-759, 2005 (abstract)
Johnson, Blake A., Therapeutic Periradicular Injections: It's a Gas! American Journal of
Neuradiology 26: 988-989, 2005. (PubMed)
Cancer/oncology
Bocci, Velio; Alessandra Larini & Vanna Micheli, Restoration of Normoxia by Ozone Therapy
May Control Neoplastic Growth: A Review and a Working Hypothesis. Journal of
Alternative and Complementary Medicine 11: 257-265, 2005. (abstract)
Dermatology
Valacchi, G.; V. Fortino & V. Bocci, The dual action of ozone on the skin. British Journal of
Dermatology 153: 1096-1100, 2005. (abstract)
GynecologyAbubakirova, A. M.; T. A. Fedorova; T. S. Foteeva; I. I. Baranov & E. M. Bakuridze, [Clinical use
of medical ozone in obstetrics and gynecology]. Akusherstvo i Ginekologiya №1, 54-57,
2002. [Written in Russian]
Rusova M. N., [Use of ozone in obstetrics and gynecology]. Akusherstvo i Ginekologiya №4, 4-7,
2003. [Written in Russian]
Asthma
Turrent, José & Silvia A. Menéndez, Ozonoterapia en el asma bronquial: bases terapéuticas para su
aplicación. Revista CENIC Ciencias Biológicas 29: 161-164, 1998.
Ophthalmology
Berson, Eliot; Juancho F. C. Remulla; Bernard Rosner; Michael A. Sandberg & Carol WiegelDiFranco, Evaluation of Patients With Retinitis Pigmentosa Receiving Electric Stimulation,
Ozonated blood, and Ocular Surgery in Cuba. Archives of Ophthalmology 115: 133-134,
1997.
Gerding, Heinrich, Evaluation of Patients With Retinitis Pigmentosa Receiving Electric
Stimulation, Ozonated blood, and Ocular Surgery in Cuba. Archives of Ophthalmology 115:
1215, 1997. (PubMed)
Lapina, I. M. & I. V. Sinel'shchikova, [Ozone therapy in ophthalmology]. Vestnik oftalmologii
(1998 Nov-Dec), 114(6), 51-4. [Written in Russian] (PubMed)
Peláez, Orfilio, Evaluation of Patients With Retinitis Pigmentosa Receiving Electric Stimulation,
Ozonated blood, and Ocular Surgery in Cuba. Archives of Ophthalmology 115:133, 1997.
(PubMed)
Peláez, Orfilio, Evaluation of Patients With Retinitis Pigmentosa Receiving Electric Stimulation,
Ozonated blood, and Ocular Surgery in Cuba. Archives of Ophthalmology 115: 1215-1216,
1997.
Dentistry and stomatology
Anon. Ozone Treatment for Dental Caries: Clinical Studies. Biological Therapies in Dentistry
21(Suppl 1.) 2005.
Anon. Safety of Ozone for Dental Therapy Established. Biological Therapies in Dentistry 21(Suppl
1.) 2005.
Abu Salem, Ola; Mousa Marashdeh; Julian Holmes & Edward lynch, Clinical management of
Deciduous Caries using Ozone. In: Ozone: The Revolution in Dentistry, Edward Lynch ed.,
pp. 155-164, Quintessence Publishing, UK, 2004.
AbuNaba’a, Layla; Hisham Al Shorman; Julian Holmes; Lars G. Pettersson; Junji Tagami &
Edward Lynch, Evidence-Based Research into Ozone Treatment in dentistry: An Overview,
In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 73-115, Quintessence
Publishing, UK, 2004.
Clifford, Chris; Julian Holmes & Edward lynch, Combining Airbrasion and Ozone, In: Ozone: The
Revolution in Dentistry, Edward Lynch ed., pp. 191-196, Quintessence Publishing, UK,
2004.
Croshaw, M. A. A catalyst for change. British Dental Journal 200(2): 63-64, 2006. (PubMed)
Dechaume, M., Hammasmädän, pulpiitin ja juurenpään granuloomien paikallinen hoito:
otsonikaasulla saavutettuja tuloksia. Suomen Hammaslääkäriseuran Toimituksia 48: 61-66,
1952. (Written in Finnish) (PubMed)
Filippi, A., Ozone in Oral Surgery - Current Status and Prospects. Ozone: Science & Engineering
19: 387-393, 1997.Filippi, A., Ozon in der Zahn-, Mund- und Kieferheilkunde. Deutsche Zanhnärztliche Zeitschrift
54(9): 538-544, 1999.
Freedman, George & Fay Goldstep, Ozone and Remineralisation Therapy – Minimally Invasive
Treatment of Dental Decay, In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp.
199-208, Quintessence Publishing, UK, 2004.
Freeman, Ruth; Julian Holmes & Edward Lynch, Ozone: a New Treatment Modality For Dentally
Anxious Patients, In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 287-294,
Quintessence Publishing, UK, 2004.
Holmes, Julian & Edward Lynch, Clinical Management of Caries Using Ozone and a Modified
ART Technique, In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 187-189,
Quintessence Publishing, UK, 2004.
Jackson, P., Difficulty with samples. British Dental Journal 200(2): 63, 2006. (PubMed)
Johnson, Newton; Julian Holmes & Edward lynch, The Implications of Using Ozone in General
Dental Practice. In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 67-72,
Quintessence Publishing, UK, 2004.
Johnson, Newton, The Introduction of Ozone Therapy into a General Dental Practice in Wales – a
Personal View, In: Ozone: The Revolution in Dentistry, Edward Lynch ed., pp. 209-213,
Quintessence Publishing, UK, 2004.
Johnson, N. D., Ozone slayers, British Dental Journal 200(2): 62-63, 2006. (PubMed)
Krasse, Bo, Can Ozone be of Value in the Medical Treatment of Dental Caries? In: Ozone: The
Revolution in Dentistry, Edward Lynch ed., pp. 11-13, Quintessence Publishing, UK, 2004.
Lynch, Edward, Management of Caries Using Ozone. In (CD-ROM): Ozone Seminar Congress,
European Cooperation of the Medical Ozone Societies, May 23
rd
-May 25
th
, Munich 2003.
(PDF)
Megighian, G. Dicran, An epistemological approach. British Dental Journal 200(2): 64, 2006.
(PubMed)
Perregaard, L., Praise for ozone. British Dental Journal 200(3): 124, 2006. (PubMed)
Steier, Liviu; Ozon in der Endodontie. Dental praxis XXII(5/6): 1-5, 2005.
Steier, L., Cochrane and Ozone. British Dental Journal 200(4): 184-185, 2006. (PubMed)
Toxicology
Bocci, V. & V. Travagli, How an ill-conceived methodological approach can condemn the medical
use of ozone therapy. International Journal of Biological Macromolecules 37(5): 287-288,
2005. (PubMed)
González, Ricardo; Cheyla Romay & Silvia Díaz-Llera, Estudios sobre genotoxicidad del ozono.
Revista Cubana de Investigaciónes Biomedicas 23: 177-183, 2004. (full text, PDF)
Autohomologous immune therapy (AHIT)
Kief, H., Die biologischen Grundlagen der autohomologen Immuntherapie. Erfahrungsheilkunde
37(3): 175-180, 1988.
Other ozone therapy related letters, comments and reviews
Cataldo, F.; How a superficial interpretation of a scientific result can be used as a pretext for the
publicity of ozone therapy. International Journal of Biological Macromolecules 37(5): 289-
290, 2005. (PubMed)English Books
Scientifically documented books written by physicians or other experts
Ali, Majid, Oxygen and Aging. Aging Healthfully, Inc., New York 2000.
Bocci, Velio, Oxygen-Ozone Therapy: A Critical Evaluation. Kluwer Academic Publishers,
Dordrecht, Netherlands, 2002. (details)
Bocci, Velio, Ozone: A new medical drug. Springer 2005. (details)
Douglass, William Campbell, Hydrogen Peroxide: Medical Miracle. Valet Publishing, Clayton,
Georgia 1990.
Lynch, Edward (Ed.), Ozone: The Revolution in Dentistry. Quintessence Publishing 2005. (details)
Viebahn-Hänsler, Renate & Andrew Lee, The Use of Ozone in Medicine: A. Practical Handbook
(4th revised ed.) 2002.
Other documented book
Altman, Nathaniel, Oxygen Healing Therapies for Optimum Health & Vitality. Healing Arts Press,
Rochester, Vermont 1998.
Non-documented books
McCabe, Ed, Oxygen Therapies, Energy Publications, Morrisville, NY, 1988.
McCabe, Ed, O3 vs. AIDS: The Abbreviated History and Suppression of Ozone Therapy in the
United States as of August 1993. USA 1993.
McCabe, Ed, Flood Your Body With Oxygen: Therapy For Our Polluted World. Energy
Publications, Miami, FL, 2002. (details)
Scientifically documented Finnish book
Sallinen, Miika, Otsoni- j