An open controlled randomised clinical trial to assess the efficacy and safety of ozonized oil (oleozon) in the treatment of AUNG were carried
out with patients from the periodontology consult of the odontology services of “Camilo Cienfuegos” University Hospital.

Mild adverse reactions were reported in patients who used sodium perborate, but not with those who used oleozon, supporting the safety of this product in the treatment of AUNG. Taking into consideration the safety profile and the lower cost, we consider that ozonized oil could be a useful and safe therapeutical alternative in patients with AUNG.

Our results showed that gastric ulcer index was significantly reduced in rats pretreated with OSO as compared with ethanol-treated controls ... demonstratingthat OSO pretreatment exerts protective effects in ethanol-induced gastric ulcers in rats. Furthermore, these results provide evidence that these protective effects of OSO are mediated at least partially by stimulation of some important antioxidant enzymes such as SOD and GSH-Px, which are scavengers of ROS and therefore prevent gastric injury induced by them.

20 patients at several hospitals who underwent surgical operation between August 1998 to August 2000 had ozonized olive oil applied to their intractable fistula or wounds. Treatment was fully effective in 19 of the cases. The one exception was for a case of pilonidal sinus.

Ozonized olive oil was especially effective in treating intractable abdominal fistula to digestive tract after surgical operation. No adverse side effects observed in the administration of the ozonized olive oil. It was fully effective for a discharge of pus and the formation of granulation.